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The impact of qualitative analysis in laboratory medicine
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Clinical Microbiology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Microbiology.
Swedish Institute for Infectious Disease Control Stockholm.
Dept of Clinical Chemistry Karolinska Univesity Hospital.
Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
2005 (English)In: TrAC. Trends in analytical chemistry, ISSN 0165-9936, Vol. 24, no 6, 546-555 p.Article in journal (Refereed) Published
Abstract [en]

Laboratory medicine is a challenge for the metrologically and terminologically inclined scientist. One main reason is the need for a sound theory that can be applied in a systematic way to cover all aspects of examinations, i.e., those procedures whose results are reported on an ordinal scale and those reported on more primitive scales (e.g., classifications and narratives). Validation of procedures for examinations involving properties on a nominal scale is especially difficult to achieve because it is hard to find gold standards, in the conventional sense, against which to validate and which combine performance characteristics and clinically relevant specificity and sensitivity. We present a systematic, unambiguously defined terminology (the C-NPU coding scheme) for metrologically derived terms for expressing properties, and present some examples of how to attain diagnostic goals. If the analytic process in the laboratory can be subsumed into medical contexts in a systematic way, many pitfalls in reporting results can be avoided. © 2005 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2005. Vol. 24, no 6, 546-555 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-28809DOI: 10.1016/j.trac.2005.03.009Local ID: 13997OAI: diva2:249621
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2011-01-12

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