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Maternal obesity and the risk for orofacial clefts in the offspring
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
2005 (English)In: The Cleft Palate-Craniofacial Journal, ISSN 1055-6656, Vol. 42, no 4, 367-371 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To estimate whether obese women have an increased risk of orofacial clefts in their offspring, compared with average-weight women. Design and Participants: The study was based on information on maternal body mass index (BMI) collected in early pregnancy and on the existence of orofacial clefts in the offspring, ascertained from multiple sources. The study included 1686 women who had infants with an orofacial cleft and as controls all delivered women (n = 988,171) during the study period, 1992 through 2001. Infants with chromosome anomalies were excluded. The women were divided into underweight (BMI <19.8), average weight (reference group, BMI 19.8 to 26), overweight (BMI 26.1 to 29), and obese (BMI >29). Adjustments were made for year of birth, maternal age, parity, and maternal smoking. Results: Obese (BMI >29) mothers had an overall increased risk for having an infant with orofacial clefts: odds ratio 1.30 (95% confidence interval 1.11 to 1.53). This increased risk was higher when the cleft was associated with other major malformations than when it was isolated. There was no statistically significant difference between the risk estimates for cleft lip and cleft palate. Conclusions: In this large sample, a positive association appears between maternal obesity in early pregnancy and orofacial clefts in the offspring. The explanation for this association is not known, but a relationship with undetected type 2 diabetes is one possibility.

Place, publisher, year, edition, pages
2005. Vol. 42, no 4, 367-371 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-28867DOI: 10.1597/04-012.1Local ID: 14061OAI: diva2:249679
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2011-01-12

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Cedergren, Marie
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Faculty of Health SciencesObstetrics and gynecologyDepartment of Gynecology and Obstetrics in Linköping
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The Cleft Palate-Craniofacial Journal
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