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Does a positive anti-CCP test identify a distinct arthritis entity?
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Rheumatology. Östergötlands Läns Landsting, Centre for Medicine, Department of Rheumatology in Östergötland.ORCID iD: 0000-0002-0153-9249
2005 (English)In: Arthritis Research and Therapy, ISSN 1478-6354, Vol. 7, no 6, 230-232 p.Article in journal (Refereed) Published
Abstract [en]

The introduction of tests recognizing 'anti-citrullinated protein antibodies' (ACPA) has caused a revolution in rheumatology. Immunization against citrullinated proteins is a feature almost unique for rheumatoid arthritis, although ACPA may occur long before the onset of symptoms. Even if the presence of ACPA does not seem to reveal a distinct arthritis phenotype at symptom onset, it predicts an aggressive disease course with unfavourable outcome. Despite the very high diagnostic specificity for rheumatoid arthritis, ACPA-positivity does not always accord with a traditional diagnosis of rheumatoid arthritis at clinical presentation. However, even when these patients are judged to suffer from mild undifferentiated arthritis, they call for follow-up and special attention by rheumatologists. © 2005 BioMed Central Ltd.

Place, publisher, year, edition, pages
2005. Vol. 7, no 6, 230-232 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-29368DOI: 10.1186/ar1836Local ID: 14698OAI: diva2:250180
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2015-08-31

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Skogh, Thomas
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Faculty of Health SciencesRheumatologyDepartment of Rheumatology in Östergötland
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