Does a positive anti-CCP test identify a distinct arthritis entity?
2005 (English)In: Arthritis Research and Therapy, ISSN 1478-6354, Vol. 7, no 6, 230-232 p.Article in journal (Refereed) Published
The introduction of tests recognizing 'anti-citrullinated protein antibodies' (ACPA) has caused a revolution in rheumatology. Immunization against citrullinated proteins is a feature almost unique for rheumatoid arthritis, although ACPA may occur long before the onset of symptoms. Even if the presence of ACPA does not seem to reveal a distinct arthritis phenotype at symptom onset, it predicts an aggressive disease course with unfavourable outcome. Despite the very high diagnostic specificity for rheumatoid arthritis, ACPA-positivity does not always accord with a traditional diagnosis of rheumatoid arthritis at clinical presentation. However, even when these patients are judged to suffer from mild undifferentiated arthritis, they call for follow-up and special attention by rheumatologists. © 2005 BioMed Central Ltd.
Place, publisher, year, edition, pages
2005. Vol. 7, no 6, 230-232 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-29368DOI: 10.1186/ar1836Local ID: 14698OAI: oai:DiVA.org:liu-29368DiVA: diva2:250180