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Reverse engineering galactose regulation in yeast through model selection
Institute for Systems Biology.
Institute for Systems Biology.
Linköping University, The Institute of Technology. Linköping University, Department of Science and Technology.ORCID iD: 0000-0003-0528-9782
Linköping University, The Institute of Technology. Linköping University, Department of Science and Technology.ORCID iD: 0000-0003-0528-9782
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2005 (English)In: Statistical Applications in Genetics and Molecular Biology, ISSN 1544-6115, E-ISSN 1544-6115, Vol. 4, no 1Article in journal (Refereed) Published
Abstract [en]

We examine the application of statistical model selection methods to reverse-engineering the control of galactose utilization in yeast from DNA microarray experiment data. In these experiments, relationships among gene expression values are revealed through modifications of galactose sugar level and genetic perturbations through knockouts. For each gene variable, we select predictors using a variety of methods, taking into account the variance in each measurement. These methods include maximization of log-likelihood with Cp, AIC, and BIC penalties, bootstrap and cross-validation error estimation, and coefficient shrinkage via the Lasso. Copyright ©2005 by the authors. All rights reserved.

Place, publisher, year, edition, pages
2005. Vol. 4, no 1
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Engineering and Technology
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URN: urn:nbn:se:liu:diva-29433Local ID: 14779OAI: oai:DiVA.org:liu-29433DiVA: diva2:250247
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13

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Hörnquist, MichaelHörnquist, Michael

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