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Identification of a Nonlinear Cell Cycle System with Linear Models
Linköping University, Department of Computer and Information Science, PELAB - Programming Environment Laboratory. Linköping University, The Institute of Technology.
Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
Linköping University, Department of Computer and Information Science, PELAB - Programming Environment Laboratory. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-3435-4996
2005 (English)In: Proceedings of the Conference on Modeling and Simulation in Biology, Medicine and Biomedical EngineeringMay 26-27, 2005, Linköping, Sweden / [ed] Peter Fritzson, Linköping, 2005, 129-138 p.Conference paper, Published paper (Refereed)
Abstract [en]

A mathematical model by Chen et al. representing the cell cycle of the budding yeast cell (Saccharomyces cerevisiae) is used to simulate levels of 13 different cell biological variables. By using a linear systems approach on the generated data the goal is to identify the original equations of the mathematical model. Since this model is described by a nonlinear system the linear systems approach only gives correct estimations of the linear parts of the system, with one exception. A main issue thus becomes to identify which data that belongs to the linear equations and which does not. This problem is solved using two local linear models on different time intervals. Parameter estimations of coefficients from linear and time invariant equations should be the same over all time intervals.

Place, publisher, year, edition, pages
Linköping, 2005. 129-138 p.
Keyword [en]
Systems biology, Cell cycle, Budding yeast, Auto regression model
National Category
Computer Science
Identifiers
URN: urn:nbn:se:liu:diva-29517Local ID: 14872OAI: oai:DiVA.org:liu-29517DiVA: diva2:250332
Conference
4th International Conference on SImulation in Medicine, Biology and Biomedical Engineering, Linköping, Sweden, May 26-27, 2005
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2014-10-08Bibliographically approved

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Fransson, MartinGerdin, MarkusFritzson, Peter

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