Analysis of the information content in sonoclot data and reconstruction of coagulation test variables
2002 (English)In: Journal of medical systems, ISSN 0148-5598, E-ISSN 1573-689X, Vol. 26, no 1, 1-8 p.Article in journal (Refereed) Published
The Sonoclot Coagulation AnalyzerTM is a viscoelastometer used for in vitro analysis of the coagulation process from the start of fibrin formation, through polymerization of the fibrin monomer, platelet interaction, and eventually to clot retraction and lysis. In this paper, we have analyzed series of Sonoclot curves and simultaneously obtained coagulation tests (APT, PT, Fibrinogen, Platelet Count, and D-dimer) from patients who underwent total hip replacements (THA). By using the Principal Component Analysis method (PCA), we found that the most important coagulation test variables as reflected in the Sonoclot signature, are Platelet Count, PT, and Fibrinogen. Also, by using a Back-Propagation Neural Network (BP), we were able to reconstruct the coagulation variables Platelet Count, PT, and Fibrinogen from the Sonoclot curve with a reasonable accuracy. This would also indicate that these three coagulation test variables are most important in determining the appearance of the Sonoclot signature.
Place, publisher, year, edition, pages
2002. Vol. 26, no 1, 1-8 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-29552DOI: 10.1023/A:1013007202250Local ID: 14923OAI: oai:DiVA.org:liu-29552DiVA: diva2:250368