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An asymmetric dialysis tube as an integrated part of a pressure-monitoring sensor
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
2001 (English)In: Technology and Health Care, ISSN 0928-7329, E-ISSN 1878-7401, Vol. 9, no 5, 417-425 p.Article in journal (Refereed) Published
Abstract [en]

A sensor has been designed consisting of a tube holder with a force transducer and a tube with a modified cross-section. The holder has a lid that encloses the tube. By having a stiff holder and a compliant tube, the idea is that the intraluminal pressure in the tube can be obtained from the measured force. The method is intended for non-invasive pressure measurements in blood or dialysate tubes.

We have used a tube cross-sectional geometry where the outer surface is elliptic and the inner surface is circular with a relation of 2:1 between the thinnest and thickest tube sides. The pressure transducer system shows a linear relationship between the applied pressure and the sensor output (r = 0.999). Within the temperature range, 32°–36°C, which corresponds to the blood and dialysate temperatures, the sensor accuracy is within ±0.8 kPa (±6 mm Hg). This indicates that the sensor should be clinically useful during dialysis and similar applications.

Place, publisher, year, edition, pages
2001. Vol. 9, no 5, 417-425 p.
Keyword [en]
Non-invasive pressure sensor, asymmetric tube, dialysis, extracorporeal tube, profile analysis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-29584Local ID: 14961OAI: oai:DiVA.org:liu-29584DiVA: diva2:250401
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13
In thesis
1. Monitoring principles for haemodialysis
Open this publication in new window or tab >>Monitoring principles for haemodialysis
2002 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis deals with non-invasive monitoring techniques for haemodialysis. Three applications in particular have been investigated: Blood pressure measurements in the extra corporal circuit, the relationship between UV measurements and dialysate urea concentration and photoplethysmography (PPG) in haemodialysis patients.

A non-invasive pressure sensor as an integrated part of the extracorporeal tube circuit was developed using modified cross-section tube geometry. The expansions of the modified tubes with different cross-sectional geometries were studied upon application of pressure, both experimentally and numerically, using the finite element method. Factorial design was used to study the relationship between pressure in the tube and force needed to restore the expanding tube to its original dimension. This investigation was performed for different tube cross-sectional geometries. A pressure sensor was designed, based on the previously obtained findings. The evaluation of the pressure sensor showed that the output corresponded well to applied pressure (R2=0.99).

An UV-method for studying waste products in the dialysate has recently been developed by our research group. In the present study, it was investigated how the relationship between UV-absorption and dialysate urea concentration was affected by the treatment settings, patient anamnesis and prescribed pharmaceuticals. A mathematical model was proposed which includes these effects. Multiregression analysis indicated the possibility of performing individual estimates of urea concentration from UV-absorption.

During haemodialysis, the patient's cardiovascular system is affected when excess fluid is extracted, which may result in blood pressure fluctuations. In the present study, a novel PPG method for monitoring haemodynamic changes during dialysis was investigated. The performed study indicates that PPG measurements relate to haemodynamic changes and may thus be useful in the patient monitoring. However, the relationship is complex and needs further studies.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2002. 45 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 737
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-24563 (URN)6728 (Local ID)91-7373-270-2 (ISBN)6728 (Archive number)6728 (OAI)
Public defence
2002-05-21, Aulan, Administrationshuset, Universitetssjukhuset, Linköping, 10:15 (Swedish)
Opponent
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2012-12-21

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Andersson, RogerAsk, Per

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