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Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Psychiatry. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
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2005 (English)In: BMC Psychiatry, ISSN 1471-244X, Vol. 5Article in journal (Refereed) Published
Abstract [en]

Background: Recent magnetic resonance spectroscopy (MRS) studies report that glutamine is altered in the brains of schizophrenic patients. There were also conflicting findings on glutamate in cerebrospinal fluid (CSF) of schizophrenic patients, and absent for glutamine. This study aims to clarify the question of glutamine and glutamate in CSF of first episode and drug naive schizophrenic patients. Method: Levels of glutamine and glutamate in CSF of 25 first episode and drug-naive male schizophrenic patients and 17 age-matched male healthy controls were measured by a high performance liquid chromatography. Results: The ratio (126.1 (median), 117.7 ± 27.4 (mean ± S.D.)) of glutamine to glutamate in the CSF of patients was significantly (z = -3.29, p = 0.001) higher than that (81.01 (median), 89.1 ± 22.5 (mean ± S.D.)) of normal controls although each level of glutamine and glutamate in patients was not different from that of normal controls. Conclusion: Our data suggests that a disfunction in glutamate-glutamine cycle in the brain may play a role in the pathophysiology of schizophrenia. © 2005 Hashimoto et al, licensee BioMed Central Ltd.

Place, publisher, year, edition, pages
2005. Vol. 5
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-30125DOI: 10.1186/1471-244X-5-6Local ID: 15604OAI: diva2:250946
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2011-01-12

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Nordin, Conny
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Faculty of Health SciencesPsychiatryDepartment of Psychiatry
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