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A comparison between in vitro studies of protein lesions generated by brain electrodes and finite element model simulations
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
Linköping University, Department of Mechanical Engineering, Fluid and Mechanical Engineering Systems. Linköping University, The Institute of Technology.
Linköping University, Department of Mechanical Engineering, Fluid and Mechanical Engineering Systems. Linköping University, The Institute of Technology.
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-0012-7867
1999 (English)In: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 37, no 6, 737-741 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to develop a finite element model for simulation of the thermal characteristics of brain electrodes and to compare its performances with an in vitro experimental albumin model. Ten lesions were created in albumin using a monopolar electrode connected to a Leksell Neuro Generator and a computer-assisted video system was used to determine the size of the generated lesions. A finite element model was set up of the in vitro experiments using the same thermal properties. With a very simple heat source applied to the finite element model in the proximity of the upper part of the tip, a good agreement (no deviations in width and distance from tip but a deviation in length of −1.6 mm) with the in vitro experiments (width 4.6±0.1 mm and length 7.4±0.1 mm) was achieved when comparing the outline of the lesion. In addition, a gelatinous albumin-model was set up and compared to computer simulations resulting in deviations in width of −0.4 mm, length of −2.2 mm and distance from the tip of −0.1 mm. Hence, the utilisation of finite element model simulations may be a useful complement to in-vitro experiments.

Place, publisher, year, edition, pages
1999. Vol. 37, no 6, 737-741 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-30204DOI: 10.1007/BF02513376Local ID: 15698OAI: oai:DiVA.org:liu-30204DiVA: diva2:251026
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13
In thesis
1. Characterisation and modelling of radio-frequency lesioning in functional neurosurgery
Open this publication in new window or tab >>Characterisation and modelling of radio-frequency lesioning in functional neurosurgery
2001 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis focuses on the characterisation and modelling of the radio frequency (RF) lesioning with emphasis on size estimation in functional neurosurgery. A computer-assisted video system has been set up for standardised test and documentation of protein clots generated by RF-lesioning electrodes in an albumin solution. A standardised test is essential in comparing assessed results of the size and shape of protein clots generated using different parameters. This is beneficial to both the manufacturer oflesioning electrodes as well as the surgeon.

In an animal study, performed analogously to thalamotomy in man, the correlation in size between in vitro protein clots and in vivo lesions has been investigated. The result shows a high correlation between protein clots and lesions observed on MR images; and lesions observed on MR images and corresponding coagulated tissue in histological sectionings. This actualises the value of presurgical electrode tests to validate the electrode function and lesion size in vitro.

A finite element model has been set-up in order to facilitate studies of the growth and the temperature distribution during the lesioning process. Of the utmost importance is the finding of a difference in temperature between maximum temperature, located outside the electrode, compared to the intra-electrode (thermocouple) temperature.

A method for real time monitoring of lesion growth and estimation of lesion size utilising static and/or Doppler broadened laser light is proposed. Implemented in a surgical-assist system, this could give valuable guidance to the surgeon as to whether the desired lesion size is obtained or not and keep the destruction precise, but to a minimum.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2001. 70 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 693
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-29440 (URN)14786 (Local ID)91-7373-033-5 (ISBN)14786 (Archive number)14786 (OAI)
Public defence
2001-06-01, Elsa Brändströmssalen, Universitetssjukhuset, Linköping, 09:15 (Swedish)
Opponent
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2013-02-26

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Eriksson, OlaWren, JoakimLoyd, DanWårdell, Karin

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