Molecular epidemiology of norovirus infections in Stockholm, Sweden, during the years 2000 to 2003: Association of the GGIIb genetic cluster with infection in children
2005 (English)In: Journal of Clinical Microbiology, ISSN 0095-1137, Vol. 43, no 3, 1086-1092 p.Article in journal (Refereed) Published
The incidence of norovirus-associated gastroenteritis and the molecular epidemiology of norovirus strains were studied during three seasons (2000-2001, 2001-2002, and 2002-2003) among patients of all ages, mainly from the Stockholm region in Sweden. A total of 3,252 fecal samples were analyzed by reverse transcription-PCR. The incidences of norovirus infection among adults were 23, 26, and 30% during the three seasons studied and 18,11, and 15% among children 0 to 15 years of age. During the first season, all norovirus strains detected by PCR were typed either by reverse line blot hybridization or nucleotide sequence analysis. During the two successive seasons, a total of 60 norovirus-positive strains from the beginning, peak, and end of the seasons were selected for nucleotide sequence analysis. We identified two dominant noroviras variants over the seasons: a new norovirus variant, recently described as the GGIIb genetic cluster, dominated among children during the first season, and during the following two seasons, a GGII-4 variant dominated. Our data suggest that norovirus infections are common, not only among adults, but also among children, and that some strains may predominantly affect children. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Place, publisher, year, edition, pages
2005. Vol. 43, no 3, 1086-1092 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-30263DOI: 10.1128/JCM.43.3.1086-1092.2005Local ID: 15774OAI: oai:DiVA.org:liu-30263DiVA: diva2:251085