Nitric oxide synthase 2 (NOS2) promoter polymorphisms in colorectal cancer
2005 (English)In: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 225, no 1, 99-103 p.Article in journal (Refereed) Published
Previously, increased expression of nitric oxide synthase 2 (NOS2) in colorectal cancer (CRC) has been identified. The NOS2 gene is transcriptionally regulated, which suggests that polymorphisms in the NOS2 promoter may have a role for CRC development and progression. The genotyping was performed with PCR/RFLP, single strand conformation analysis or MegaBACE genotyping of normal blood DNA from CRC patients and normal healthy controls. However, no significant association between NOS2 polymorphisms and CRC onset or clinical outcome was evident. In conclusion, these results, therefore, suggest that NOS2 promoter polymorphisms have a limited effect on the onset or progression of CRC.
Place, publisher, year, edition, pages
2005. Vol. 225, no 1, 99-103 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-30426DOI: 10.1016/j.canlet.2005.02.006Local ID: 15988OAI: oai:DiVA.org:liu-30426DiVA: diva2:251248