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Protein fibrils in nature can enhance amyloid protein A amyloidosis in mice: Cross-seeding as a disease mechanism
Division of Pathology, Karolinska University Hospital, Huddinge, Sweden.
Linköping University, Department of Biomedicine and Surgery, Cell biology. Linköping University, Faculty of Health Sciences.
Department of Clinical Immunology, Göteborg University, Göteborg, Sweden.
Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden.
2005 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 102, no 17, 6098-6102 p.Article in journal (Refereed) Published
Abstract [en]

Secondary, or amyloid protein A (AA), amyloidosis is a complication of chronic inflammatory diseases, both infectious and noninfectious. AA constitutes the insoluble fibrils, which are deposited in different organs, and is a major N-terminal part of the acute phase protein serum AA. It is not known why only some patients with chronic inflammation develop AA amyloidosis. Nucleation is a widely accepted mechanism in amyloidogenesis. Preformed amyloid-like fibrils act as nuclei in amyloid fibril formation in vitro, and AA amyloid fibrils and synthetic amyloid-like fibrils also may serve as seed for fibril formation in vivo. In addition to amyloid fibrils, there is a variety of similar nonmammalian protein fibrils with β-pleated structure in nature. We studied three such naturally occurring protein fibrils: silk from Bombyx mori, Sup35 from Saccharomyces cerevisiae, and curli from Escherichia coli. Our results show that these protein fibrils exert amyloid-accelerating properties in the murine experimental AA amyloidosis, suggesting that such environment factors may be important risk factors in amyloidogenesis.

Place, publisher, year, edition, pages
2005. Vol. 102, no 17, 6098-6102 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-30441DOI: 10.1073/pnas.0501814102Local ID: 16004OAI: diva2:251263
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2012-09-03Bibliographically approved

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Lundmark, KatarzynaWestermark, Gunilla
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Cell biologyFaculty of Health Sciences
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