Is aggregate IAPP a cause of beta-cell failure in transplanted human pancreatic islets?
2005 (English)In: Current Diabetes Reports, ISSN 1534-4827, Vol. 5, no 3, 184-188 p.Article in journal (Refereed) Published
Aggregation of the β-cell product islet amyloid polypeptide (IAPP) is believed to be an important event in the development of the β-cell lesion in type 2 diabetes. Preamyloidotic oligomeric IAPP assemblies exert toxic effects on β cells that die, leading to reduced β-cell mass. Normal human islets, when isolated and cultured in vitro or transplanted into nude mice, also develop amyloid deposits, which are associated with increased β-cell death and reduced β-cell mass. The possible role of IAPP aggregation and amyloid formation in loss of islet transplant function should be taken into consideration and studied further. Copyright © 2005 by Current Science Inc.
Place, publisher, year, edition, pages
2005. Vol. 5, no 3, 184-188 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-30504Local ID: 16082OAI: oai:DiVA.org:liu-30504DiVA: diva2:251326