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Is aggregate IAPP a cause of beta-cell failure in transplanted human pancreatic islets?
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of cell biology.
2005 (English)In: Current Diabetes Reports, ISSN 1534-4827, E-ISSN 1539-0829, Vol. 5, no 3, 184-188 p.Article in journal (Refereed) Published
Abstract [en]

Aggregation of the β-cell product islet amyloid polypeptide (IAPP) is believed to be an important event in the development of the β-cell lesion in type 2 diabetes. Preamyloidotic oligomeric IAPP assemblies exert toxic effects on β cells that die, leading to reduced β-cell mass. Normal human islets, when isolated and cultured in vitro or transplanted into nude mice, also develop amyloid deposits, which are associated with increased β-cell death and reduced β-cell mass. The possible role of IAPP aggregation and amyloid formation in loss of islet transplant function should be taken into consideration and studied further. Copyright © 2005 by Current Science Inc.

Place, publisher, year, edition, pages
2005. Vol. 5, no 3, 184-188 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-30504Local ID: 16082OAI: oai:DiVA.org:liu-30504DiVA: diva2:251326
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13

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