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Sex steroid regulation of angiogenesis in breast tissue
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
2005 (English)In: Angiogenesis, ISSN 0969-6970, Vol. 8, no 2, 127-136 p.Article in journal (Refereed) Published
Abstract [en]

Angiogenesis is essential for normal function in the female reproductive tract and a prerequisite for growth and metastasis of solid tumors. Several factors, both inducers and inhibitors, play essential roles in the regulation of the angiogenic process. Exposure to sex steroids increases the risk of breast cancer but the mechanisms are poorly understood and the importance of angiogenesis in breast carcinogenesis is undefined. In the female reproductive tract ovarian hormones tightly regulate angiogenesis. The breast is also a target organ for sex steroids but very little is known about sex steroid effects on angiogenesis in normal breast tissue and breast cancer. In this review several regulators of angiogenesis, and their relation to sex steroids, in breast tissue are discussed. Increased knowledge in this area is of utmost importance for future therapeutic treatment options and for breast cancer prevention. © Springer 2005.

Place, publisher, year, edition, pages
2005. Vol. 8, no 2, 127-136 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-30506DOI: 10.1007/s10456-005-9002-0Local ID: 16084OAI: diva2:251328
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2011-01-12

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Dabrosin, Charlotta
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Faculty of Health SciencesOncologyDepartment of Oncology UHL
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