A randomized multicenter study to compare two treatment regimens of topical methyl aminolevulinate (Metvix®)-PDT in actinic keratosis of the face and scalp
2005 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, Vol. 85, no 5, 424-428 p.Article in journal (Refereed) Published
Photodynamic therapy (PDT) with topical methyl aminolevulinate (MAL) administered in two treatment sessions separated by 1 week is an effective treatment for actinic keratoses. This open prospective study compared the efficacy and safety of MAL-PDT given as a single treatment with two treatments of MAL-PDT 1 week apart. Two hundred and eleven patients with 413 thin to moderately thick actinic keratoses were randomized to either a single treatment with PDT using topical MAL (regimen I, n=105) or two treatments 1 week apart (regimen II, n=106). Each treatment involved surface debridement, application of Metvix® cream (160 mg/g) for 3 h, followed by illumination with red light using a light-emitting diode system (peak wavelength 634±3 nm, light dose 37 J/cm2). Thirty-seven lesions (19%) with a non-complete response 3 months after a single treatment were re-treated. All patients were followed up 3 months after the last treatment. A total of 400 lesions, 198 initially treated once and 202 treated twice, were evaluable. Complete response rate for thin lesions after a single treatment was 93% (95% CI=87-97%), which was similar to 89% (82-96%) after repeated treatment. Response rates were lower after single treatment of thicker lesions (70% (60-78%) vs 84% (77-91%)), but improved after repeated treatment (88% (82-94%)). The conclusion of this study is that single treatment with topical MAL-PDT is effective for thin actinic keratosis lesions, however, repeated treatment is recommended for thicker or non-responding lesions. © 2005 Taylor & Francis.
Place, publisher, year, edition, pages
2005. Vol. 85, no 5, 424-428 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-30525DOI: 10.1080/00015550510032887Local ID: 16106OAI: oai:DiVA.org:liu-30525DiVA: diva2:251347