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A randomized multicenter study to compare two treatment regimens of topical methyl aminolevulinate (Metvix®)-PDT in actinic keratosis of the face and scalp
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of dermatology and venereology. Östergötlands Läns Landsting, Centre for Medicine, Department of Dermatology and Venerology in Östergötland.
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2005 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, Vol. 85, no 5, 424-428 p.Article in journal (Refereed) Published
Abstract [en]

Photodynamic therapy (PDT) with topical methyl aminolevulinate (MAL) administered in two treatment sessions separated by 1 week is an effective treatment for actinic keratoses. This open prospective study compared the efficacy and safety of MAL-PDT given as a single treatment with two treatments of MAL-PDT 1 week apart. Two hundred and eleven patients with 413 thin to moderately thick actinic keratoses were randomized to either a single treatment with PDT using topical MAL (regimen I, n=105) or two treatments 1 week apart (regimen II, n=106). Each treatment involved surface debridement, application of Metvix® cream (160 mg/g) for 3 h, followed by illumination with red light using a light-emitting diode system (peak wavelength 634±3 nm, light dose 37 J/cm2). Thirty-seven lesions (19%) with a non-complete response 3 months after a single treatment were re-treated. All patients were followed up 3 months after the last treatment. A total of 400 lesions, 198 initially treated once and 202 treated twice, were evaluable. Complete response rate for thin lesions after a single treatment was 93% (95% CI=87-97%), which was similar to 89% (82-96%) after repeated treatment. Response rates were lower after single treatment of thicker lesions (70% (60-78%) vs 84% (77-91%)), but improved after repeated treatment (88% (82-94%)). The conclusion of this study is that single treatment with topical MAL-PDT is effective for thin actinic keratosis lesions, however, repeated treatment is recommended for thicker or non-responding lesions. © 2005 Taylor & Francis.

Place, publisher, year, edition, pages
2005. Vol. 85, no 5, 424-428 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-30525DOI: 10.1080/00015550510032887Local ID: 16106OAI: diva2:251347
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2011-01-12

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Rosdahl, Inger
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Faculty of Health SciencesDivision of dermatology and venereologyDepartment of Dermatology and Venerology in Östergötland
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