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Microvascular arteriovenous shunting is a probable pathogenetic mechanism in erythromelalgia
National Hospital, Department of Dermatology, Oslo, Norway.
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
Ullevaal Hospital, Department of Cardiothoracic Surgery, University of Oslo, Norway.
2000 (English)In: Journal of Investigative Dermatology, ISSN 0022-202X, E-ISSN 1523-1747, Vol. 114, no 4, 643-646 p.Article in journal (Refereed) Published
Abstract [en]

Erythromelalgia is a condition consisting of red, warm, and burning painful extremities. Symptoms are relieved by cold and aggravated by heat. A wide variety of etiologic conditions can cause erythromelalgia, but one common pathogenetic mechanism, microvascular arteriovenous shunting, has been hypothesized. The aim of this study was to test this hypothesis. Quantification of skin microvascular perfusion using laser Doppler perfusion imaging and skin temperature at rest and after central body heating was performed in 14 patients with erythromelalgia and 11 controls. Attacks of erythromelalgia were induced in eight patients after heat provocation. In the plantar region of the foot, the location of numerous anatomical arteriovenous shunts, these patients significantly increased the skin perfusion as compared with asymptomatic patients with erythromelalgia and controls. In the dorsal region with few arteriovenous shunts no significant differences between the groups were demonstrated. The results show a relation between clinical symptoms and increased perfusion in the region of numerous anatomical arteriovenous shunts, and support the hypothesis of increased thermoregulatory arteriovenous shunt flow during attacks in primary erythromelalgia.

Place, publisher, year, edition, pages
2000. Vol. 114, no 4, 643-646 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-30590DOI: 10.1046/j.1523-1747.2000.00944.xLocal ID: 16181OAI: oai:DiVA.org:liu-30590DiVA: diva2:251413
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13
In thesis
1. Computer assisted video microscopy: in characterization of capillary ensembles
Open this publication in new window or tab >>Computer assisted video microscopy: in characterization of capillary ensembles
2000 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis focuses on evaluation and analysis of capillary microcirculatory changes in the skin, that can be improved and extended by computer assisted video microscopy. Capillary microscopy has been used extensively, both in clinical practice and research, to study different phenomena in the microvasculature of the skin, mainly in the nailfold of fingers and toes where a large portion of the capillary loop can be observed.

In the majority of the different skin regions, the nutritive capillary network approaches the skin surface perpendicularly and capillary microscopy in these sites reveals the apex of the capillary loop as a dark spot. The main approach in this work has been to study a large ensemble of capillary loops, in order to apply statistical and planar models whilst, at the same time, obtaining spatial parameters related to the capillary localization.

The statistical models of proximity are based on nearest neighbour methods and triangulation techniques. The main reason for introducing these models is because of their capability to characterize the heterogeneity of the capillary ensemble.

A computer assisted video microscopy system, that enables both capturing and evaluating of capillary bed images, was assembled and was, thereafter, successfully used in laboratory and clinical studies.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2000. 64 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 648
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-29442 (URN)14788 (Local ID)91-7219-822-2 (ISBN)14788 (Archive number)14788 (OAI)
Public defence
2000-09-12, Berzeliussalen, Universitetssjukhuset, Linköping, 09:00 (Swedish)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2013-02-27

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Salerud, Göran

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