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Induction of inflammation as a possible mechanism of probiotic effect in atopic ezema-dermatitis syndrome
Finland .
Finland .
Finland .
Finland .
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2005 (English)In: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, E-ISSN 1097-6825, Vol. 115, no 6, 1254-1259 p.Article in journal (Refereed) Published
Abstract [en]

Background

The immunomodulating mechanisms of Lactobacillus GG (LGG) and other probiotics are poorly understood.

Objective

We studied in vivo the immunologic effects of probiotics in infants with atopic eczema–dermatitis syndrome (AEDS) and cow's milk allergy (CMA).

Methods

Two hundred thirty infants with AEDS and suspected CMA received, concomitant with elimination diet, either LGG, a mixture of 4 probiotic strains (MIX), or placebo for 4 weeks. All available paired pretreatment and posttreatment plasma samples (n = 132) were analyzed for concentrations of IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ, soluble intercellular adhesion molecule 1, soluble E-selectin, TGF-β1, TGF-β2, and C-reactive protein.

Results

In infants with IgE-associated AEDS, treatment with LGG induced higher C-reactive protein levels than in the placebo group (geometric mean, 0.83 μg/mL [95% CI, 0.56-0.81] vs 0.42 μg/mL [95% CI, 0.27-0.65]; P = .021). Concomitantly, IL-6 levels increased after treatment with LGG (P = .023) but not with MIX or placebo. Soluble E-selectin levels were higher after probiotic than after placebo treatment in infants with IgE-mediated CMA (LGG geometric mean, 86.7 ng/mL [95% CI, 75.2-100]; MIX geometric mean, 91.6 ng/mL [95% CI, 74.8-111.9]; and placebo geometric mean, 64.9 ng/mL [95% CI, 53-79.3]; analysis of covariance, P = .035; LGG vs placebo, P = .023; MIX vs placebo, P = .020). Use of MIX induced an increase in plasma IL-10 levels (P = .016).

Conclusion

Probiotics induced systemically detectable low-grade inflammation, which might explain the clinical effects of probiotics in AEDS and CMA.

Place, publisher, year, edition, pages
2005. Vol. 115, no 6, 1254-1259 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-30853DOI: 10.1016/j.jaci.2005.03.047Local ID: 16512OAI: oai:DiVA.org:liu-30853DiVA: diva2:251676
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13

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Vaarala, Outi

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