liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Induction of inflammation as a possible mechanism of probiotic effect in atopic ezema-dermatitis syndrome
Finland .
Finland .
Finland .
Finland .
Show others and affiliations
2005 (English)In: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, E-ISSN 1097-6825, Vol. 115, no 6, 1254-1259 p.Article in journal (Refereed) Published
Abstract [en]


The immunomodulating mechanisms of Lactobacillus GG (LGG) and other probiotics are poorly understood.


We studied in vivo the immunologic effects of probiotics in infants with atopic eczema–dermatitis syndrome (AEDS) and cow's milk allergy (CMA).


Two hundred thirty infants with AEDS and suspected CMA received, concomitant with elimination diet, either LGG, a mixture of 4 probiotic strains (MIX), or placebo for 4 weeks. All available paired pretreatment and posttreatment plasma samples (n = 132) were analyzed for concentrations of IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ, soluble intercellular adhesion molecule 1, soluble E-selectin, TGF-β1, TGF-β2, and C-reactive protein.


In infants with IgE-associated AEDS, treatment with LGG induced higher C-reactive protein levels than in the placebo group (geometric mean, 0.83 μg/mL [95% CI, 0.56-0.81] vs 0.42 μg/mL [95% CI, 0.27-0.65]; P = .021). Concomitantly, IL-6 levels increased after treatment with LGG (P = .023) but not with MIX or placebo. Soluble E-selectin levels were higher after probiotic than after placebo treatment in infants with IgE-mediated CMA (LGG geometric mean, 86.7 ng/mL [95% CI, 75.2-100]; MIX geometric mean, 91.6 ng/mL [95% CI, 74.8-111.9]; and placebo geometric mean, 64.9 ng/mL [95% CI, 53-79.3]; analysis of covariance, P = .035; LGG vs placebo, P = .023; MIX vs placebo, P = .020). Use of MIX induced an increase in plasma IL-10 levels (P = .016).


Probiotics induced systemically detectable low-grade inflammation, which might explain the clinical effects of probiotics in AEDS and CMA.

Place, publisher, year, edition, pages
2005. Vol. 115, no 6, 1254-1259 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-30853DOI: 10.1016/j.jaci.2005.03.047Local ID: 16512OAI: diva2:251676
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2010-05-20

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Vaarala, Outi
In the same journal
Journal of Allergy and Clinical Immunology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 52 hits
ReferencesLink to record
Permanent link

Direct link