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Influence of tissue phantom optical properties and emitting - receiving fiber distance on Laser Doppler flowmetry
Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation.ORCID iD: 0000-0001-6385-6760
Faculty of Applied Physics University of Twente, Enschede, NL.
Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation.
2000 (English)In: Progress in Biomedical Optics and Imaging,2000, San José: SPIE , 2000, 56-63 p.Conference paper (Refereed)
Abstract [en]

The influence of emitting - receiving fiber distance on the perfusion signal in laser Doppler flowmetry (LDF) for a range of optical properties has been studied. A custom made LDF probe with eight 230 μm fibers arranged in a row was used. Measurements were made on a tissue phantom with three different sets of optical properties (P={μs; μa} [mm-1]; P1={14.7; 0.212}, P2={44.9; 0.226} and P3=(45.6; 0.0532}). A single moving disc simulated flow at four different depths. The noise-corrected perfusion for a given set of optical properties (P), fiber distance (l) and disc depth (d) is defined as Perf(ν,P,d,l)=k(P,d,l) v, where v is the speed of the rotating disc. The relative difference between two slopes, Δk(Pa,Pb,l,d), indicates how sensitive the LDF readings are to changes in optical properties (Pb → Pa) for given disc depth and fiber distance. Evaluation of Δk(P1,P2,d,l) (reflects changes in scattering coefficient, μs) and Δk(P3,P2,d,l) (reflects changes in absorption coefficient, μa) indicated that LDF perfusion was more sensitive to the changes in μs than in μa. The sensitivity also increased with increasing disc depth. A fiber distance of 920 [μm] was found to minimize these effects. E.g. the sensitivity due to the variations in μs, for fiber distance l1=920, l2=230 [μm] and for all disc depths, was Δk(P1,P2,l1)=[0.76, 1.06, 1.58, 2.40] and Δk(P1,P2,l2)=[1.61, 2.98, 5.04, 7.67].

Place, publisher, year, edition, pages
San José: SPIE , 2000. 56-63 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-31007DOI: 10.1117/12.387125Local ID: 16699ISBN: 0-8194-3539-2OAI: diva2:251830
Optical diagnostics of biological fluids V, 27 January 2000, San Jose, California, USA
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2016-08-31

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