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Whole blood coagulation on protein adsorption-resistant PEG and peptide functionalised PEG-coated titanium surfaces
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
Linköping University, The Institute of Technology. Linköping University, Department of Science and Technology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.ORCID iD: 0000-0002-6916-5490
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2005 (English)In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 26, no 8, 861-872 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate whole blood coagulation on low blood plasma protein adsorbing surfaces. For this purpose, the polycationic graft copolymer poly(L-lysine)-g-poly(ethylene glycol) (PLL-g-PEG), PLL-g-PEG grafted with a cell adhesive peptide containing the amino acid sequence -Arg-Gly-Asp- (RGD), and PLL-g-PEG with a control peptide -Arg-Asp-Gly- (RDG) were adsorbed onto titanium (oxide), forming stable monomolecular adlayers through electrostatic attraction. Free oscillation rheometry and complementary techniques were used to measure the coagulation time (CT) and other interactions of the surfaces with native whole blood, recalcified platelet-rich plasma (PRP), and recalcified citrated platelet-free plasma (PFP). The results show that the uncoated titanium surfaces (reference) activated platelets and quickly triggered the coagulation cascade via the intrinsic pathway, whereas the PLL-g-PEG surfaces displayed a prolonged CT, approximately 2-3 times longer compared to uncoated titanium. We hypothesise that blood coagulates outside the vascular system independent of low protein adsorption to or activation by surfaces, due to the absence of an active down-regulation of procoagulative processes by the vascular endothelium.

Place, publisher, year, edition, pages
2005. Vol. 26, no 8, 861-872 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-31048DOI: 10.1016/j.biomaterials.2004.03.036Local ID: 16765OAI: oai:DiVA.org:liu-31048DiVA: diva2:251871
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13

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Hansson, KennyIsaksson, JoakimWetterö, JonasLindahl, TomasTengvall, Pentti

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Department of Physics, Chemistry and BiologyThe Institute of TechnologyDepartment of Science and TechnologyFaculty of Health SciencesMedical MicrobiologyDivision of clinical chemistryDepartment of Clinical ChemistryApplied Physics
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