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Implications of emerging risk factors for therapeutic intervention
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2005 (English)In: NMCD. Nutrition Metabolism and Cardiovascular Diseases, ISSN 0939-4753, Vol. 15, no 5, 373-381 p.Article in journal (Refereed) Published
Abstract [en]

Recently, the National Cholesterol Education Panel (NCEP) of the United States of America commented on the implications of new clinical trials for the Adult Treatment Panel III (ATP III) guidelines [Grundy SM, Cleeman JI, Merz CN, Brewer Jr HB, Clark LT, Hunninghake DB, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004,110:227-39]. In this commentary, new categories of "moderately high" and "very high" coronary risk were proposed with new "therapeutic options" for low-density lipoprotein (LDL) cholesterol of ≤ 100 mg/dL and ≤70 mg/dL respectively. In ATP III, these "moderately high" risk patients had been classified as moderate risk with an LDL treatment goal of ≤130 mg/dL, while the "very high" risk patients had been classified as high risk with a treatment goal of ≤100 mg/dL. Risk classification in the new NCEP publication is based essentially on the combination of the Framingham risk score plus counting of classical risk factors. In the present document, the International Task Force for Prevention of Coronary Heart Disease responds to this NCEP commentary and supports the suggestion of more intensive LDL cholesterol lowering in particular cases. However, the Task Force feels that a classification based on a combination of a risk score plus a count of emerging risk factors is a more logical way to identify such patients requiring lower LDL cholesterol levels than a scheme in which classical risk factors are taken into account twice, once in a count and once in a risk score. © 2005 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
2005. Vol. 15, no 5, 373-381 p.
Keyword [en]
Coronary heart disease, Risk factors, ATP III guidelines, Risk category
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Medical and Health Sciences
URN: urn:nbn:se:liu:diva-31060DOI: 10.1016/j.numecd.2005.06.011Local ID: 16780OAI: diva2:251883
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2011-01-12

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Olsson, Anders
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Faculty of Health SciencesInternal MedicineDepartment of Endocrinology and Gastroenterology UHL
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NMCD. Nutrition Metabolism and Cardiovascular Diseases
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