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Kinetics of sedimentation rate, viral load and TNF-α in relation to HIV co-infection in tuberculosis
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.
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2006 (English)In: Transactions of the Royal Society of Tropical Medicine and Hygiene, ISSN 0035-9203, E-ISSN 1878-3503, Vol. 100, no 5, 483-488 p.Article in journal (Refereed) Published
Abstract [en]

The kinetics of potential surrogate markers in HIV-positive (HIV+) and HIV-negative (HIV-), smear-positive tuberculosis (Tb+) patients in Gondar, Ethiopia (n = 60) was investigated. Clinical symptoms, sputum conversion, sedimentation rate (SR), HIV viral load and serum levels of TNF-α were determined before and 8 weeks after treatment initiation. The co-infection rate of HIV was 45%. There were significantly higher initial levels of SR and TNF-α in HIV+/Tb+ patients (79 ± 29 mm/h and 13.5 ± 7.6 pg/ml), than in HIV-/Tb+ patients (60 ± 23 mm/h and 6.8 ± 5.9 pg/ml, P < 0.001). In HIV-/Tb+ patients, there was a marked decrease in SR compared with co-infected patients (46% [33 ± 24 mm/h at week 8] vs. 24% [61 ± 27 mm/h at week 8]). The HIV viral load (4.99 [range 3.70-5.92] to 4.90 [range 3.96-5.78] log10 copies/ml from week 0 to 8) and TNF-α (13.5 ± 7.6 to 12.0 ± 6.0 pg/ml) remained high in HIV+/Tb+ patients. In Tb patients, SR was significantly increased in HIV+ compared with HIV- patients. Additionally, TNF-α and HIV viral load remained elevated in HIV+/ Tb+ patients following treatment despite clinical improvement comparable to HIV-/Tb+ patients. © 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

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2006. Vol. 100, no 5, 483-488 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-31066DOI: 10.1016/j.trstmh.2005.07.018Local ID: 16786OAI: oai:DiVA.org:liu-31066DiVA: diva2:251889
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13

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Schön, ThomasStendahl, OlleSundqvist, Tommy

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