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Significance of Cox-2 expression in rectal cancers with or without preoperative radiotherapy
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of dermatology and venereology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
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2005 (English)In: International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, Vol. 63, no 3, 739-744 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: Radiotherapy has reduced local recurrence of rectal cancers, but the result is not satisfactory. Further biologic factors are needed to identify patients for more effective radiotherapy. Our aims were to investigate the relationship of cyclooxygenase-2 (Cox-2) expression to radiotherapy, and clinicopathologic/biologic variables in rectal cancers with or without radiotherapy. Methods and Materials: Cox-2 expression was immunohistochemically examined in distal normal mucosa (n = 28), in adjacent normal mucosa (n = 107), in primary cancer (n = 138), lymph node metastasis (n = 30), and biopsy (n = 85). The patients participated in a rectal cancer trial of preoperative radiotherapy. Results: Cox-2 expression was increased in primary tumor compared with normal mucosa (p < 0.0001), but there was no significant change between primary tumor and metastasis. Cox-2 positivity was or tended to be related to more p53 and Ki-67 expression, and less apoptosis (p ≤ 0.05). In Cox-2-negative cases of either biopsy (p = 0.01) or surgical samples (p = 0.02), radiotherapy was related to less frequency of local recurrence, but this was not the case in Cox-2-positive cases. Conclusion: Cox-2 expression seemed to be an early event involved in rectal cancer development. Radiotherapy might reduce a rate of local recurrence in the patients with Cox-2 weakly stained tumors, but not in those with Cox-2 strongly stained tumors. © 2005 Elsevier Inc.

Place, publisher, year, edition, pages
2005. Vol. 63, no 3, 739-744 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-31080DOI: 10.1016/j.ijrobp.2005.02.031Local ID: 16807OAI: oai:DiVA.org:liu-31080DiVA: diva2:251903
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2011-01-12

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Zhang, HongAdell, GunnarSun, Xiao-Feng

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Zhang, HongAdell, GunnarSun, Xiao-Feng
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Faculty of Health SciencesDivision of dermatology and venereologyOncologyDepartment of Oncology UHL
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