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Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients' survival
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of cell biology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of surgery. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology.
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2005 (English)In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 11, no 43, 6875-6879 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To examine whether polymorphisms in SULT1A1 and GSTP1 genes contribute to colorectal cancer development and whether they are associated with clinicopathological variables are not well identified. Methods: We examined the genotypes of 125 colorectal cancer patients and 666 healthy controls in a Swedish population by using PCR restriction fragment length polymorphism (RFLP). Results: SULT1A1 *2/*2 genotype (OR = 2.49, 95%CI = 1.48-4.19, P = 0.0002) and *2 allele (OR = 1.56, 95%CI = 1.16-2.10, P = 0.002) had an effect on colorectal cancer susceptibility, while GSTP1 genotype was without effect. However, GSTP1 G-type predicted a worse prognosis in the patients independently of gender, age, Dukes' stage, growth pattern, and differentiation (P = 0.03). Conclusion: Polymorphism in SULT1A1 may predispose to colorectal cancer and GSTP1 may be a biological indicator of prognosis in the patients. © 2005 The WJG Press and Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
2005. Vol. 11, no 43, 6875-6879 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-31173Local ID: 16912OAI: oai:DiVA.org:liu-31173DiVA: diva2:251996
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13

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Sun, Xiao-FengAhmadi, AhmadArbman, GunnarWallin, ÅsaZhang, Hong

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Sun, Xiao-FengAhmadi, AhmadArbman, GunnarWallin, ÅsaZhang, Hong
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Faculty of Health SciencesOncologyDepartment of Oncology UHLDivision of cell biologyDivision of surgeryDepartment of Surgery in ÖstergötlandDivision of dermatology and venereology
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World Journal of Gastroenterology
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