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An immune risk phenotype, cognitive impairment, and survival in very late life: Impact of allostatic load in Swedish octogenarian and nonagenarian humans
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2005 (English)In: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, Vol. 60, no 5, 556-565 p.Article in journal (Refereed) Published
Abstract [en]

In the previous OCTO longitudinal study, we identified an immune risk phenotype (IRP) of high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated that cognitive impairment constitutes a major predictor of nonsurvival. In the present NONA longitudinal study, we simultaneously examine in a model of allostatic load IRP and compromised cognition in 4-year survival in a population-based sample (n = 138, 86-94 years). Immune system measurements consisted of determinations of T-cell subsets, plasma interleukin 6 and cytomegalovirus and Epstein-Barr virus serology. Interleukin 2 responsiveness to concanavalin A, using data from the previous OCTO (octogenarians) immune study, hereafter OCTO immune, was also examined. Cognitive status was rated using a battery of neuropsychological tests. Logistic regression indicated that the IRP and cognitive impairment together predicted 58% of observed deaths. IRP was associated with late differentiated CD8+CD28-CD27 - cells (p < .001), decreased interleukin 2 responsiveness (p < .05) and persistent viral infection (p < .01). Cognitive impairment was associated with increased plasma interleukin 6 (p < .001). IRP individuals with cognitive impairment were all deceased at the follow-up, indicating an allostatic overload. Copyright 2005 by The Gerontological Society of America.

Place, publisher, year, edition, pages
2005. Vol. 60, no 5, 556-565 p.
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Medical and Health Sciences
URN: urn:nbn:se:liu:diva-31237Local ID: 16990OAI: diva2:252060
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2011-01-12

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Ernerudh, Jan
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Faculty of Health SciencesClinical ImmunologyDepartment of Clinical Immunology and Transfusion Medicine
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