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Subcutaneous adipocytes from obese hyperinsulinemic women with polycystic ovary syndrome exhibit normal insulin sensitivity but reduced maximal insulin responsiveness
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
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2005 (English)In: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 153, no 6, 831-835 p.Article in journal (Refereed) Published
Abstract [en]

Background: Polycystic ovary syndrome (PCOS) has a high prevalence in women and is often associated with insulin resistance and hence with aspects of the so-called metabolic syndrome. Methods: Ten women diagnosed with PCOS were consecutively included (aged 21-39 years, average 30.2±1.9 years, body mass index 28.4-42.5 kg/m2, average 37.5±1.7 kg/m2 (mean±S.E.)). Adipocytes were isolated from the subcutaneous fat and, after overnight incubation to recover from insulin resistance due to the surgical cell isolation procedures, they were analyzed for insulin sensitivity. Results: The patients with PCOS exhibited marked clinical hyperinsulinemia with 3.6-fold higher blood levels of C-peptide than a healthy lean control group (1.7±0.2 and 0.5±0.02 nmol/l respectively, P < 0.0001). The patients with PCOS also exhibited 2.4-fold higher concentrations of serum triacylglycerol (2.1±0.3 and 0.9±0.06 mmol/l respectively, P < 0.0001), but only slightly elevated blood pressure (118±12/76±6 and 113±7/72±6 mmHg respectively, P = 0.055/0.046). However, insulin sensitivity for stimulation of glucose transport in the isolated adipocytes was indistinguishable from a non-PCOS, non-diabetic control group, while the maximal insulin effect on glucose uptake was significantly lower (2.2±0.2- and 3.8±0.8-fold respectively, P = 0.02). Conclusions: Subcutaneous adipocytes from patients with PCOS do not display reduced insulin sensitivity. The findings show that the insulin resistance of PCOS is qualitatively different from that of type 2 diabetes. © 2005 Society of the European Journal of Endocrinology.

Place, publisher, year, edition, pages
2005. Vol. 153, no 6, 831-835 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-31484DOI: 10.1530/eje.1.02027Local ID: 17276OAI: oai:DiVA.org:liu-31484DiVA: diva2:252307
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13

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Lystedt, ErikaBrynhildsen, JanLindh-Åstrand, LottaGustavsson, JohannaNyström, FredrikHammar, MatsStrålfors, Peter

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Lystedt, ErikaBrynhildsen, JanLindh-Åstrand, LottaGustavsson, JohannaNyström, FredrikHammar, MatsStrålfors, Peter
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Faculty of Health SciencesDepartment of Medicine and CareObstetrics and gynecologyDepartment of Gynecology and Obstetrics in LinköpingDivision of cell biologyInternal MedicineDepartment of Endocrinology and Gastroenterology UHL
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European Journal of Endocrinology
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