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Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Psychiatry. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
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2005 (English)In: Progress in Neuro-psychopharmacology and Biological Psychiatry, ISSN 0278-5846, Vol. 29, no 5, 767-769 p.Article in journal (Refereed) Published
Abstract [en]

Several lines of evidence suggest that d-serine, an endogenous agonist of the glycine site on the NMDA receptors, might play a role in the pathophysiology of schizophrenia. The purpose of this study was to determine whether levels of d- and l-serine or d-serine ratio (d-serine/total serine) in cerebrospinal fluid (CSF) were altered in first episode and drug-naive schizophrenic patients. The CSF levels of d- and l-serine in 25 male first episode and drug-naive schizophrenic patients and 17 age-matched male healthy subjects were measured using a column-switching high performance liquid chromatography system. The percentage of d-serine in the total serine of patients was significantly (z = - 2.01, p = 0.044) lower than that of controls. This study suggests that synthetic or metabolic pathways of d-serine may be abnormal in the brain of drug-naive schizophrenic patients, supporting the NMDA receptor dysfunction hypothesis of schizophrenia. © 2005 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
2005. Vol. 29, no 5, 767-769 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-31799DOI: 10.1016/j.pnpbp.2005.04.023Local ID: 17624OAI: oai:DiVA.org:liu-31799DiVA: diva2:252622
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2011-01-12

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Nordin, Conny

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