Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients
2005 (English)In: Progress in Neuro-psychopharmacology and Biological Psychiatry, ISSN 0278-5846, Vol. 29, no 5, 767-769 p.Article in journal (Refereed) Published
Several lines of evidence suggest that d-serine, an endogenous agonist of the glycine site on the NMDA receptors, might play a role in the pathophysiology of schizophrenia. The purpose of this study was to determine whether levels of d- and l-serine or d-serine ratio (d-serine/total serine) in cerebrospinal fluid (CSF) were altered in first episode and drug-naive schizophrenic patients. The CSF levels of d- and l-serine in 25 male first episode and drug-naive schizophrenic patients and 17 age-matched male healthy subjects were measured using a column-switching high performance liquid chromatography system. The percentage of d-serine in the total serine of patients was significantly (z = - 2.01, p = 0.044) lower than that of controls. This study suggests that synthetic or metabolic pathways of d-serine may be abnormal in the brain of drug-naive schizophrenic patients, supporting the NMDA receptor dysfunction hypothesis of schizophrenia. © 2005 Elsevier Inc. All rights reserved.
Place, publisher, year, edition, pages
2005. Vol. 29, no 5, 767-769 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-31799DOI: 10.1016/j.pnpbp.2005.04.023Local ID: 17624OAI: oai:DiVA.org:liu-31799DiVA: diva2:252622