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Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to VH gene mutation status
Umeå University.
Linköping University, Department of Biomedicine and Surgery, Oncology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Haematology UHL.
Uppsala University.
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2005 (English)In: Blood, ISSN 0006-4971, Vol. 105, no 12, 4807-4812 p.Article in journal (Refereed) Published
Abstract [en]

B-cell chronic lymphocytic leukemia (CLL) consists of 2 prognostic entities where cases with mutated immunoglobulin VH genes have better outcome than unmutated cases. VH-mutated CLLs display longer telomeres compared with unmutated cases and telomere length has been indicated to predict outcome, although the prognostic value of telomere length has not been fully established in CLL. We analyzed telomere length, VH gene mutation status, and clinical parameters in a large series of CLL. Telomere length was assessed by quantitative polymerase chain reaction (PCR), giving a very good correlation to telomere length estimated by Southern blotting (P < .001). The prognostic information given by mutation status (n = 282) and telomere length (n = 246) was significant (P < .001, respectively). Telomere length was a prognostic factor for stage A (P = .021) and stage B/C (P = .018) patients, whereas mutation status predicted outcome only in stage A patients (P < .001). Furthermore, mutated CLLs were subdivided by telomere length into 2 groups with different prognoses (P = .003), a subdivision not seen for unmutated cases (P = .232). Interestingly, the VH-mutated group with short telomeres had an overall survival close to that of the unmutated cases. Thus, by combining VH mutation status and telomere length, an improved subclassification of CLL was achieved identifying previously unrecognized patient groups with different outcomes. (Blood. 2005;105:4807-4812)

Place, publisher, year, edition, pages
2005. Vol. 105, no 12, 4807-4812 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-31887DOI: 10.1182/blood-2004-11-4394.PubMedID: 15746080Local ID: 17719OAI: diva2:252710
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2010-03-12

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