Cytotoxic effect of a lipophilic alkylating agent after incorporation into low density lipoprotein or emulsions: Studies in human leukemic cells
2006 (English)In: Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, ISSN 0145-2126, Vol. 30, no 2, 136-144 p.Article in journal (Refereed) Published
The use of low density lipoprotein (LDL) as drug carrier in acute myeloblastic leukemia chemotherapy is attractive due to high LDL uptake by leukemic cells. Lipid-based formulations, such as liposomes or microemulsions are promising alternatives. In the current study, we incorporated N-trifluoroacetyl-adriamycin-14-valerate (AD32), a lipophilic derivative of daunorubicin (DNR), and WB4291, a lipophilic alkylating agent, into LDL or lipid microemulsions and evaluated their cytotoxic activities towards leukemic cell lines using as references DNR and melphalan. The incorporation of AD32 into LDL or emulsion resulted in complexes with poor cytotoxicity. WB4291-LDL and WB4291-emulsion exerted, on the other hand, promising cytotoxic effects towards parental and resistant K562 and HL60 cell lines. © 2005 Elsevier Ltd. All rights reserved.
Place, publisher, year, edition, pages
2006. Vol. 30, no 2, 136-144 p.
LDL, Lipid emulsion, Acute myeloid leukemia, DNR, Melphalan
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-32085DOI: 10.1016/j.leukres.2005.06.012Local ID: 17941OAI: oai:DiVA.org:liu-32085DiVA: diva2:252907