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Cytotoxic effect of a lipophilic alkylating agent after incorporation into low density lipoprotein or emulsions: Studies in human leukemic cells
Karolinska, Stockholm.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Pharmacology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pharmacology.
Karolinska, Stockholm.
2006 (English)In: Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, ISSN 0145-2126, Vol. 30, no 2, 136-144 p.Article in journal (Refereed) Published
Abstract [en]

The use of low density lipoprotein (LDL) as drug carrier in acute myeloblastic leukemia chemotherapy is attractive due to high LDL uptake by leukemic cells. Lipid-based formulations, such as liposomes or microemulsions are promising alternatives. In the current study, we incorporated N-trifluoroacetyl-adriamycin-14-valerate (AD32), a lipophilic derivative of daunorubicin (DNR), and WB4291, a lipophilic alkylating agent, into LDL or lipid microemulsions and evaluated their cytotoxic activities towards leukemic cell lines using as references DNR and melphalan. The incorporation of AD32 into LDL or emulsion resulted in complexes with poor cytotoxicity. WB4291-LDL and WB4291-emulsion exerted, on the other hand, promising cytotoxic effects towards parental and resistant K562 and HL60 cell lines. © 2005 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2006. Vol. 30, no 2, 136-144 p.
Keyword [en]
LDL, Lipid emulsion, Acute myeloid leukemia, DNR, Melphalan
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-32085DOI: 10.1016/j.leukres.2005.06.012Local ID: 17941OAI: diva2:252907
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2011-01-11

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Peterson, Curt
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Faculty of Health SciencesClinical PharmacologyDepartment of Clinical Pharmacology
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Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis
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