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The effect of percutaneous dilatation of renal arterial stenosis on captopril renography in hypertension
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Medical Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Rheumatology. Östergötlands Läns Landsting, Centre for Medicine, Department of Rheumatology in Östergötland.ORCID iD: 0000-0002.3555-7162
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2005 (English)In: Blood Pressure, ISSN 0803-7051, Vol. 14, no 6, 359-365 p.Article in journal (Refereed) Published
Abstract [en]

Background. The clinical effects of percutaneous transluminal renal artery angioplasty (PTRA) in patients with renal vascular stenosis and hypertension is controversial. Methods. We consecutively recruited all 23 patients referred for evaluation of renovascular hypertension that eventually underwent unilateral PTRA, to be investigated with captopril MAG3 renography (CR), both before and after the endovascular procedure. Data were evaluated on an intention-to-treat basis. Results. We found that the relative MAG3 clearance of the stenotic kidney increased (from 29.9 ± 14% to 35.1 ± 14%, p=0.01) and that the creatinine levels fell following the intervention (from 110 ± 19 to 99 ± 17 μmol/l, p=0.0003). Blood pressure levels were also lowered (from 173 ± 32/93 ± 17 to 158 ± 31/86 ± 15 mmHg, p<0.006) while the mean number of anti-hypertensive drugs was unchanged following PTRA (2.9 ± 1.4 before and 2.8 ± 1.3 drugs after the intervention, respectively, p-0.6). Conclusion. This prospective trial showed statistically significant improvements of individual kidney function as measured by CR and blood pressure in subjects with suspected renovascular hypertension treated with PTRA. Although the endovascular procedure was found to be safe, the magniture of the absolute improvements was rather modest. © 2005 Taylor & Francis.

Place, publisher, year, edition, pages
2005. Vol. 14, no 6, 359-365 p.
Keyword [en]
Captopril, hypertension, outcome, renal artery stenosis, renography
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-32367DOI: 10.1080/08037050500339275Local ID: 18264OAI: oai:DiVA.org:liu-32367DiVA: diva2:253189
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2013-10-25

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Granerus, GöranStenström, HugoEriksson, PerNyström, Fredrik

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Faculty of Health SciencesClinical PhysiologyDepartment of Clinical PhysiologyMedical RadiologyDepartment of Radiology UHLRheumatologyDepartment of Rheumatology in ÖstergötlandInternal MedicineDepartment of Endocrinology and Gastroenterology UHL
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