The electric charge of pigment granules in pigment cells
2001 (English)In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 16, no 1-2, 31-36 p.Article in journal (Refereed) Published
Black pigment cells called melanophores change colour in response to environmental changes and have lately been studied as promising biosensors. To further elucidate the intracellular processes involved in the colour changes of these cells, and to find optimal biosensing principles, the electric charge of intracellular pigment granules, melanosomes, has been determined in vitro by electrophoresis. Melanosomes from the two extreme states in the cell colour change (aggregated and dispersed melanosomes) were measured. The charge was found to be −1.5·10−16 and −1.7·10−16 C, aggregated and dispersed melanosomes, respectively, without significant difference between the two conditions. This charge is of the same order of magnitude as the one of 1000 electrons. The origin of the melanosome charge, and the use of these findings in new biosensor principles, is discussed.
Place, publisher, year, edition, pages
2001. Vol. 16, no 1-2, 31-36 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-32560DOI: 10.1016/S0956-5663(00)00130-5Local ID: 18473OAI: oai:DiVA.org:liu-32560DiVA: diva2:253383