Influence of pericardial suction blood retransfusion on memory function and release of protein S100B
2004 (English)In: Perfusion, ISSN 0267-6591, Vol. 19, no 6, 337-343 p.Article in journal (Refereed) Published
Background: To study the influence of pericardial suction blood (PSB) on postoperative memory disturbances and release patterns of protein S100B during and after cardiopulmonary bypass (CPB). Methods: Sixty male patients admitted for coronary artery bypass surgery were prospectively randomized to receive PSB either by using conventional cardiotomy suction retransfusion or after cell-saver processing. Results: The concentration of S100B rose during the period of CPB from 0.065 ± 0.004 to 0.24 ± 0.001 μg/L (p <0.001). PSB contained 18.0 ± 1.7 μg/L of S100B. Direct retransfusion from the cardiotomy reservoir made the systemic level increase to 1.42 ± 0.19 μg/L compared to 0.25±0.02 μg/L using a cell-saver. Signs of postoperative memory dysfunction (>1 SD) were discovered in one of three tests, but were unrelated to technique of retransfusion. No associations were found between serum concentrations of S100B and memory function. Conclusion: In this study, retransfusion of PSB during cardiac surgery appeared not to cause memory disturbances. PSB contained high concentrations of protein S100B making its use as a marker of cerebral injury unsuitable. © Arnold 2004.
Place, publisher, year, edition, pages
2004. Vol. 19, no 6, 337-343 p.
IdentifiersURN: urn:nbn:se:liu:diva-33018DOI: 10.1191/0267659104pf768oaLocal ID: 18979OAI: oai:DiVA.org:liu-33018DiVA: diva2:253841