Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: A novel therapeutic approach
2005 (English)In: Clinical Cancer Research, ISSN 1078-0432, Vol. 11, no 13, 4674-4680 p.Article in journal (Refereed) Published
Craniopharyngioma is a rare benign intracranial epithelial tumor that, however, often recurs and sometimes kills the affected patients, one-third of which are children. In many cases, the patients acquire growth hormone deficiency and postoperatively need substitution. Generally, growth hormone promotes local release of insulin-like growth factor I (IGF-I), which in turn activates the IGF-I receptor (IGF-IR) if present. Together, these circumstances raise the question whether IGF-IR may be involved in craniopharyngioma growth. To address this issue, we analyzed phenotypically well-characterized primary low-passage craniopharyngioma cell lines from nine different patients for IGF-IR expression and IGF-I dependency. Two of the cell lines showed no/very low expression of the receptor and was independent on IGF-I, whereas five cell lines exhibited a strong expression and was clearly contingent on IGF-I. The two remaining cell lines had low receptor expression and IGF-I dependency. Upon treatment with an IGF-IR inhibitor, cells with high IGF-IR expression responded promptly with decreased Akt phosphorylation followed by growth arrest. These responses were not seen in cells with no/very low receptor expression. Growth of cell lines with tow IGF-IR expression was only slightly affected by IGF-IR inhibition. Taken together, our data suggest that IGF-IR may be involved in the growth of a subset of craniopharyngiomas and points to the possibility of the involvement of IGF-IR inhibitors as a treatment modality to obtain complete tumor-free conditions before growth hormone substitution. © 2005 American Association for Cancer Research.
Place, publisher, year, edition, pages
2005. Vol. 11, no 13, 4674-4680 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-33241DOI: 10.1158/1078-0432.CCR-05-0129Local ID: 19240OAI: oai:DiVA.org:liu-33241DiVA: diva2:254064