Higher platelet P-selectin in male patients with inflammatory bowel disease compared to healthy males
2006 (English)In: World Journal of Gastroenterology, ISSN 1007-9327, Vol. 12, no 8, 1270-1272 p.Article in journal (Refereed) Published
Aim: To observe if the total amount of platelet P-selectin (tP-selectin) in patients with inflammatory bowel disease (IBD) was related to disease entity or activity, 5-aminosalicylic acid (5-ASA) medication or gender. Methods: tP-selectin was measured by immunoassay in seventeen IBD patients and twelve healthy controls. Results: Compared to controls, there was no difference of tP-selectin in patients related to disease entity or activity and 5-ASA medication. When the groups were split according to gender the male patient group showed higher levels of tP-selectin compared to male controls (153 ng/mL vs 94 ng/mL, P<0.05). Conclusion: Increased tP-selectin levels may alter the inflammatory response and susceptibility to thromboembolic disease. As previously shown with soluble P-selectin, tP-selectin shows gender dependent differences important to consider in future studies. © 2006 The WJG Press. All rights reserved.
Place, publisher, year, edition, pages
2006. Vol. 12, no 8, 1270-1272 p.
Platelet, P-selectin, inflammatory bowel disease, 5-aminosalicylic acid, gender
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-33444Local ID: 19463OAI: oai:DiVA.org:liu-33444DiVA: diva2:254267