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Higher platelet P-selectin in male patients with inflammatory bowel disease compared to healthy males
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.ORCID iD: 0000-0003-3184-0427
2006 (English)In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 12, no 8, 1270-1272 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To observe if the total amount of platelet P-selectin (tP-selectin) in patients with inflammatory bowel disease (IBD) was related to disease entity or activity, 5-aminosalicylic acid (5-ASA) medication or gender. Methods: tP-selectin was measured by immunoassay in seventeen IBD patients and twelve healthy controls. Results: Compared to controls, there was no difference of tP-selectin in patients related to disease entity or activity and 5-ASA medication. When the groups were split according to gender the male patient group showed higher levels of tP-selectin compared to male controls (153 ng/mL vs 94 ng/mL, P<0.05). Conclusion: Increased tP-selectin levels may alter the inflammatory response and susceptibility to thromboembolic disease. As previously shown with soluble P-selectin, tP-selectin shows gender dependent differences important to consider in future studies. © 2006 The WJG Press. All rights reserved.

Place, publisher, year, edition, pages
2006. Vol. 12, no 8, 1270-1272 p.
Keyword [en]
Platelet, P-selectin, inflammatory bowel disease, 5-aminosalicylic acid, gender
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-33444Local ID: 19463OAI: oai:DiVA.org:liu-33444DiVA: diva2:254267
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13

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Fägerstam, PatrikWhiss, Per A

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