Pharyngeal carriage of serogroup W135 Neisseria meningitidis in Hajjees and their family contacts in Morocco, Oman and Sudan
2005 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 113, no 3, 182-186 p.Article in journal (Refereed) Published
In 2000 the global outbreak that began in Saudi Arabia was caused by a W135:2a:P1.5,2 strain of Neisseria meningitidis belonging to the ET-37 complex and to ST-11. There was concern that introduction of this epidemic clone (EC) might lead to a wave of outbreaks in the African meningitis belt. The WHO therefore initiated studies of meningococcal carriage among pilgrims and their family contacts in Morocco, Oman and Sudan, 3 to 12 months after the Hajj 2000. In Morocco, 1186 persons were swabbed 3 times. Ninety-five meningococcal strains were isolated from 2.7% of the specimens. Pulsed-field gel electrophoresis showed that 32 (33.6%) were identical with the EC. In Sudan, 5 strains identical with the EC were obtained after sampling 285 persons. In Oman, among 18 meningococcal strains isolated from 399 subjects, 11 (61.1%) belonged to the EC. The important pharyngeal carriage of W135 (EC) and its role in the 2001–2002 outbreaks in Burkina Faso argues for the necessity of reinforcing surveillance, and adapting and planning responses in Africa and the Middle East using the most appropriate vaccine.
Place, publisher, year, edition, pages
2005. Vol. 113, no 3, 182-186 p.
Neisseria meningitides, meningococcus, meningococcal meningitis, multilocus sequence typing, pulsed-field gel electrophoresis, molecular epidemiology, sequence type, clonal complex, serogroup W135
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-33471DOI: 10.1111/j.1600-0463.2005.apm1130305.xLocal ID: 19494OAI: oai:DiVA.org:liu-33471DiVA: diva2:254294