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Symptoms of multiple sclerosis in women in relation to sex steroid exposure
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Neurology. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
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2006 (English)In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 54, no 2, 149-153 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate if women with multiple sclerosis (MS) experience changes in MS symptoms related to pregnancy, the postpartum period, menopause or use of oral contraception (OC) or postmenopausal hormone therapy (HT). Methods: Women with diagnosed MS were recruited from registers of all MS patients known in two counties of Sweden, respectively. Ninety-four women were recruited in Linköping and 52 in Sundsvall. The women answered a questionnaire with categorized alternatives regarding their MS symptoms related to menstruation, pregnancy, delivery, menopause and use of OC or HT. Results: Forty percent of the women reported worsening of MS symptoms related to menopause, whereas 56% reported no change of symptoms and 5% reported decreased symptoms. More than a fourth of the women reported decreased symptoms during pregnancy, 64% reported unchanged symptoms and 10% reported increased symptoms. Every third woman reported increased symptoms after delivery, 59% reported no change and 5% reported decreased symptoms. Few women reported changes in MS symptoms in relation to use of HT or OC. Conclusion: The presented data indicate a relationship between high-oestrogen states and ameliorated symptoms whereas low-oestrogen states seem to relate to a worsening of the disease. A majority of women, however, reported no changes in MS symptoms in relation to the different oestrogen states. © 2005 Elsevier Ireland Ltd. All rights reserved.

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2006. Vol. 54, no 2, 149-153 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-34584DOI: 10.1016/j.maturitas.2005.10.003Local ID: 22151OAI: oai:DiVA.org:liu-34584DiVA: diva2:255432
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13

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Hammar, MatsLandtblom, Anne-MarieBrynhildsen, Jan

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Faculty of Health SciencesObstetrics and gynecologyDepartment of Gynecology and Obstetrics in LinköpingNeurologyDepartment of Neurology
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