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Coeliac disease and risk of renal disease - A general population cohort study
Kliniskt ForskningsCentrum, Universitetssjukhuset, Örebro.
Clinical Epidemiology Unit, Karolinska sjukhuset, Stockholm.
Avd för Pediatrik, Södersjukhuset, Stockholm.
Clinical Epidemiology Unit, Karolinska sjukhuset, Stockholm.
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2006 (English)In: Nephrology, Dialysis and Transplantation, ISSN 0931-0509, Vol. 21, no 7, 1809-1815 p.Article in journal (Refereed) Published
Abstract [en]

Background. Coeliac disease (CD) may be a risk factor for renal disease. Methods. We investigated the risk of any form of glomerulonephritis (GN) (acute, chronic and non-specified), chronic glomerulonephritis (CGN) and renal replacement therapy including dialysis treatment and kidney transplantation (KT) in patients with CD in a general population-based cohort study. We used Cox regression to assess the risk of renal disease in 14 336 patients who had received a diagnosis of CD (1964-2003) and 69 875 reference individuals matched for age, calendar year, sex and county. Patients were identified using the Swedish Hospital Discharge Registry. Follow-up began 1 year after study entry. Results. CD was associated with an increased risk of any form of GN (hazard ratio (HR)=1.64, 95% confidence intervals (CI)=1.01-2.66, P=0.046, 89 events), CGN (HR=2.65, 95% CI=1.34-5.24, P=0.005, 39 events), dialysis (HR=3.48, 95% CI=2.26-5.37, P<0.001, 102 positive events) and KT (HR=3.15, 95% CI=1.29-7.71, P=0.012, 22 events). Conclusion. We suggest that immune characteristics associated with CD increase the risk of chronic renal disease. Individuals with CD may also be at a moderately increased risk of any form of GN. © 2006 Oxford University Press.

Place, publisher, year, edition, pages
2006. Vol. 21, no 7, 1809-1815 p.
Keyword [en]
auto-immune, coeliac, cohort study, diabetes mellitus, kidney, renal disease
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-34900DOI: 10.1093/ndt/gfl117Local ID: 23892OAI: diva2:255748
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Ludvigsson, Johnny
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Faculty of Health SciencesPediatricsDepartment of Paediatrics in Linköping
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