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Liver vessel enhancement by Gd-BOPTA and Gd-EOB-DTPA- a comparison in healthy volunteers
Department of Radiology, CLINTEC, Stockholm, Sweden.
Linköping University, Department of Medicine and Care. Linköping University, Center for Medical Image Science and Visualization (CMIV). Department of Radiology, Hudiksvall Hospital, Sweden.ORCID iD: 0000-0002-4111-1693
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Medical Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-7750-1917
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Medical Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-9446-6981
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2006 (English)In: ISMRM 2006,2006, 2006Conference paper, Published paper (Other academic)
Place, publisher, year, edition, pages
2006.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-34967Local ID: 24315OAI: oai:DiVA.org:liu-34967DiVA: diva2:255815
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2014-06-27
In thesis
1. Quantitative Evaluation of Contrast Agent Dynamics in Liver MRI
Open this publication in new window or tab >>Quantitative Evaluation of Contrast Agent Dynamics in Liver MRI
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The studies presented here evaluate the biliary, parenchymal and vascular enhancement effects of two T1-shortening liver-specific contrast agents, Gd-BOPTA and Gd-EOB-DTPA, in Magnetic Resonance Imaging (MRI) of healthy subjects and of patients.

Ten healthy volunteers were examined with both contrast agents in a 1.5 T MRI system using three-dimensional gradient echo sequences for dynamic imaging until five hours after injection. The enhancement of the common hepatic duct in contrast to the liver parenchyma was analyzed in the first study. This was followed by a study of the image contrasts of the hepatic artery, portal vein and middle hepatic vein versus the liver parenchyma.

While Gd-EOB-DTPA gave an earlier and more prolonged enhancement and image contrast of the bile duct, Gd-BOPTA achieved higher maximal enhancement and higher image contrast for all vessels studied during the arterial and portal venous phases. There was no significant difference in the maximal enhancement obtained in the liver parenchyma.

In a third study, another 10 healthy volunteers were examined with the same protocol in another 1.5 T MRI system. Using signal normalization and a more quantitative, pharmacokinetic analysis, the hepatocyte-specific uptake of Gd-EOB-DTPA and Gd-BOPTA was calculated. A significant between-subjects correlation of the uptake estimates was found and the ratio of these uptake rates was of the same magnitude as has been reported in pre-clinical studies. The procedure also enabled quantitative analysis of vascular enhancement properties of these agents. Gd-BOPTA was found to give higher vessel-to-liver contrast than Gd-EOB-DTPA when recommended doses were given.

In the final study, retrospectively gathered datasets from patients with hepatobiliary disease were analyzed using the quantitative estimation of hepatic uptake of Gd-EOB-DTPA described in the third study. The uptake rate estimate provided significant predictive ability in separating normal from disturbed hepatobiliary function, which is promising for future evaluations of regional and global liver disease.

In conclusion, the differing dynamic enhancement profiles of the liver-specific contrast agents presented here can be beneficial in one context and challenging in another. Diseases of the liver and biliary system may affect the vasculature, parenchyma or biliary excretion, or a combination of these. The clinical context in terms of the relative importance of vascular, hepatic parenchymal and biliary processes should therefore determine the contrast agent for each patient and examination. A quantitative approach to analysis of contrast-enhanced liver MRI examinations is feasible and may prove valuable for their interpretation.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2010. 93 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1196
Keyword
Liver, spleen, hepatobiliary system, liver function, MRI, DCE-MRI, Gd-EOBDTPA, Gd-BOPTA, pharmacokinetic, hepatocyte, relaxivity.
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-60264 (URN)978-91-7393-338-4 (ISBN)
Public defence
2010-11-05, Elsa Brändströmsalen, Hälsouniversitetet, Campus US, Linköpings universitet, Linköping, 09:00 (English)
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Available from: 2010-10-08 Created: 2010-10-08 Last updated: 2017-01-31Bibliographically approved

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Dahlström, NilsSmedby, ÖrjanPersson, Anders

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Department of Medicine and CareCenter for Medical Image Science and Visualization (CMIV)Faculty of Health SciencesMedical RadiologyDepartment of Radiology UHL
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