The AST/ALT ratio as an indicator of cirrhosis in patients with PBC
2006 (English)In: Liver international (Print), ISSN 1478-3223, Vol. 26, no 7, 840-845 p.Article in journal (Refereed) Published
Objectives: A non-invasive, simple and non-expensive test to predict cirrhosis would be highly desirable. The aspartate aminotransferase/ alanine aminotransferase (AST/ALT) ratio has been proven to be such an indicator of cirrhosis in alcoholic liver disease, hepatitis C. Aim: To test whether the AST/ALT ratio is a marker of cirrhosis also in patients with primary biliary cirrhosis (PBC). Methods: The study consisted of 160 patients. In 126 patients, we had clinical and laboratory data at the time of diagnosis and follow-up with outcome: liver-related death, liver transplantation and survival. In 121 patients, we had laboratory data and liver histology. Results: We found that the AST/ALT ratio was significantly higher in cirrhotic patients than in non-cirrhotic patients. A high AST/ALT ratio was significantly associated with esophageal varices and ascites. In a multivariate analysis, bilirubin and ALP were predictors of poor prognosis. Conclusion: The AST/ALT ratio seems to be of clinical value as a hint to the diagnosis of cirrhosis in patients with PBC but not as a prognostic factor. © 2006 Blackwell Munksgaard.
Place, publisher, year, edition, pages
2006. Vol. 26, no 7, 840-845 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-34984DOI: 10.1111/j.1478-3231.2006.01304.xLocal ID: 24465OAI: oai:DiVA.org:liu-34984DiVA: diva2:255832