In vitro Th2 deviation of myelin-specific peripheral blood lymphocytes from patients with multiple sclerosis
2006 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, Vol. 171, no 1-2, 156-162 p.Article in journal (Refereed) Published
This study aimed at investigating if selective ex vivo immune deviation of myelin-specific cytokine secretion towards Th2 is possible in blood cells from patients with multiple sclerosis (MS). Interleukin (IL)-4 (Th2) and interferon-γ (Th1) secreting cells were recorded by ELISPOT in 13 MS patients. Deviation was successful in 10 patients. Interleukin-4 alone was most effective in inducing myelin-specific immune deviation in MS patients whereas IL-1 or IL-15 in combination with IL-4 did not improve the results. Further studies and improvements are needed before ex vivo immune deviation can be considered a potential treatment in patients with MS. © 2005 Elsevier B.V. All rights reserved.
Place, publisher, year, edition, pages
2006. Vol. 171, no 1-2, 156-162 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-35143DOI: 10.1016/j.jneuroim.2005.09.013Local ID: 25105OAI: oai:DiVA.org:liu-35143DiVA: diva2:255991