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Leishmania donovani requires functional Cdc42 and Rac1 to prevent phagosomal maturation
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.
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2006 (English)In: Infection and Immunity, ISSN 0019-9567, E-ISSN 1098-5522, Vol. 74, no 5, 2613-2618 p.Article in journal (Refereed) Published
Abstract [en]

Leishmania donovani promastigotes survive inside macrophage phagosomes by inhibiting phagosomal maturation. The main surface glycoconjugate on promastigotes, lipophosphoglycan (LPG), is crucial for survival and mediates the formation of a protective shell of F-actin around the phagosome. Previous studies have demonstrated that this effect involves inhibition of protein kinase Cα. The present study shows that functional Cdc42 and Rac1 are required for the formation of F-actin around L. donovani phagosomes. Moreover, we present data showing that phagosomes containing LPG-defective L. donovani, which is unable to induce F-actin accumulation, display both elevated levels of periphagosomal F-actin and impaired phagosomal maturation in macrophages with permanently active forms of Cdc42 and Rac1. We conclude that L. donovani engages Cdc42 and Rac1 to build up a protective coat of F-actin around its phagosome to prevent phagosomal maturation. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Place, publisher, year, edition, pages
2006. Vol. 74, no 5, 2613-2618 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-35218DOI: 10.1128/IAI.74.5.2613-2618.2006Local ID: 25767OAI: oai:DiVA.org:liu-35218DiVA: diva2:256066
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13

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Lerm, MariaHolm, ÅsaSärndahl, EvaMagnusson, Karl-EricRasmusson, Birgitta

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