Cell cycle dependent regulation of deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5′-nucleotidase I activity in MOLT-4 cells
2006 (English)In: Nucleosides, Nucleotides & Nucleic Acids, ISSN 1525-7770, Vol. 25, no 9-11, 1201-1204 p.Article in journal (Refereed) Published
Activation of nucleoside analogues is dependent on kinases and 5′-nucleotidases and the balance between the activity of these enzymes. The purpose of this study was to analyze deoxycytidine kinase, deoxyguanosine kinase, and 4 different 5′-nucleotidases during cell cycle progression in MOLT-4 cells. The activity of both kinases was cell cycle dependent and increased during proliferation while the activity of cytosolic 5′-nucleotidase I decreased. We could show that the kinase activity was higher than the total nucleotidase activity, which was unchanged or decreased during cell cycle progression. These data may be important in designing modern combination therapy with nucleoside analogues. Copyright © Taylor & Francis Group, LLC.
Place, publisher, year, edition, pages
2006. Vol. 25, no 9-11, 1201-1204 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-35541DOI: 10.1080/15257770600894386Local ID: 27511OAI: oai:DiVA.org:liu-35541DiVA: diva2:256389