liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Abnormal expression and clinicopathologic significance of p120-catenin in lung cancer
Show others and affiliations
2006 (English)In: Histology and Histopathology, ISSN 0213-3911, Vol. 21, no 7-9, 841-847 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate the relationship between the expression of p120ctn in human lung squamous cell carcinoma, adenocarcinoma and its clinicopathologic significance. The expression of p120ctn in tumors and adjacent normal lung tissues from 143 patients was examined by immunohistochemistry and Western blot. Expression of p120ctn occurs mainly in the cell membrane of normal bronchial mucosa. Abnormal expression of p120ctn, including cytoplasmic and reduced membranous expression, was found in 114 of 143 specimens (79.7%) and was significantly associated with poor differentiation, high TNM stage, and lymph node metastasis (P<0.05 for each) but not with histologic subtype. The Kaplan-Meier survival test revealed that abnormal expression of p120ctn was related to poor survival (P<0.001). A Cox regression analysis revealed that abnormal p120ctn expression was an independent factor in predicting patient survival (P=0.024). Compared with that in normal lung tissues, membranous protein level was lower in tumors (P=0.003). Abnormal expression of p120ctn is associated with tumor progression and poor prognosis in lung squamous cell carcinoma and adenocarcinoma. Reduced expression or even the absence of p120ctn isoform 1 and 3 in tumor cell membranes may be responsible for the abnormal expression of p120ctn that has been found in lung cancer.

Place, publisher, year, edition, pages
2006. Vol. 21, no 7-9, 841-847 p.
Keyword [en]
Catenin, Lung cancer, p120 ctn, Prognosis
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-35651Local ID: 28052OAI: diva2:256499
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

Open Access in DiVA

No full text

Search in DiVA

By author/editor
Yuan, Xi Ming
By organisation
Faculty of Health SciencesPathology
In the same journal
Histology and Histopathology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 33 hits
ReferencesLink to record
Permanent link

Direct link