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The influence of adhesive and invasive properties of Staphylococcus aureus defective in fibronectin-binding proteins on secretion of interleukin-6 by human endothelial cells
Örebro .
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Clinical Microbiology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Microbiology.
2006 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, Vol. 114, no 2, 112-116 p.Article in journal (Refereed) Published
Abstract [en]

Fibronectin-binding proteins (FnBP) are surface adhesins of Staphylococcus aureus documented to be virulence attributes in, for example, endovascular infections. By using mutants of S. aureus defective in the FnBPA and B genes we have investigated whether these adhesins affect cytokine expression in human umbilical vein endothelial cells (HUVEC). S. aureus expressing FnBPA and B adhered to and were internalized into HUVEC to a greater extent compared to mutants defective in expression of FnBP. Production and release of IL-6 was higher from endothelial cells infected with the parent FnBP-expressing strain compared to the FnBP-defective mutants. These results indicate that adhesion to and invasion of S. aureus into endothelial cells are important regulators of cytokine expression. © 2006 The Authors.

Place, publisher, year, edition, pages
2006. Vol. 114, no 2, 112-116 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-35746DOI: 10.1111/j.1600-0463.2006.apm_319.xLocal ID: 28400OAI: diva2:256594
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Kihlström, Erik
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Faculty of Health SciencesClinical MicrobiologyDepartment of Clinical Microbiology
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