liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Role of nitric oxide during rotavirus infection
Show others and affiliations
2006 (English)In: Journal of Medical Virology, ISSN 0146-6615, Vol. 78, no 7, 979-985 p.Article in journal (Refereed) Published
Abstract [en]

The pathophysiological mechanisms behind rotavirus-induced diarrhoea still remain incomplete. Current views suggest that the non-structural protein 4 (NSP4) of rotavirus and the enteric nervous system (ENS) participate in water secretion and diarrhoea. In the present work the role of nitric oxide (NO) in rotavirus infection and disease has been studied in vitro, mice and humans. Incubation of human intestinal epithelial cells (HT-29) with purified NSP4 but not with infectious virus produced NO2/NO3 accumulation in the incubation media. The NSP4-induced release of NO metabolites occurred within the first minutes after the addition of the toxin. Mice infected with murine rotavirus (strain EDIM) accumulated NO2/NO3 in the urine at the onset for diarrhoea. Following rotavirus infection, inducible nitric oxide synthetase (iNOS) mRNA was upregulated in ileum, but not in duodenum or jejunum of newborn pups within 5 days post-infection. A prospective clinical study including 46 children with acute rotavirus infection and age-matched controls concluded that rotavirus infection stimulates NO production during the course of the disease (P < 0.001). These observations identify NO as an important mediator of host responses during rotavirus infection. © 2006 Wiley-Liss, Inc.

Place, publisher, year, edition, pages
2006. Vol. 78, no 7, 979-985 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-35942DOI: 10.1002/jmv.20650Local ID: 29105OAI: diva2:256790
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Sundqvist, TommySvensson, Lennart
By organisation
Faculty of Health SciencesMedical MicrobiologyMolecular Virology
In the same journal
Journal of Medical Virology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 14 hits
ReferencesLink to record
Permanent link

Direct link