Application of fMRI in clinical situations
2006 (English)Licentiate thesis, comprehensive summary (Other academic)
Since its discovery in the early 1990's functional MRI (fMRI) has become the most widely used technique for mapping of brain functions. Its non-invasiveness and the large number of MR-scanners have contributed to the popularity of fMRI. In recent years the interest in using fMRI as a clinical instrument has increased, primarily for pre-operative planning. The purpose of this work is to improve the applicability of fMRI to clinical situations.
In order to attain the objectives the capacity of analysis methods for fMRI was evaluated, design of paradigms to suit patients was looked into and the effects of an anxiolytic was investigated.
Especially when fMRI is used in the clinic it is crucial that the analysis method employed is sensitive and reliable. It was confirmed that the method developed by Friman et al. is a worthy competitor to other analysis methods. In general the abilities of patients are reduced compared with healthy volunteer subjects. Therefore one has to design the tasks and task instructions to be readily comprehensible. In addition it is not uncommon that patients are anxious before the examinations and the unfamiliar environment in the MR department. Some need a small dose of an anxiolytic to be able to undergo the examination. The effect of an anxiolytic on healthy volunteers was evaluated. No effects on the fMRI results was identified but the results were confounded by a large session effect.
Place, publisher, year, edition, pages
Linköping: Linköpings universitet , 2006. , 83 p.
Linköping Studies in Health Sciences. Thesis, ISSN 1100-6013 ; 76
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-36015Local ID: 29386ISBN: 91-85497-79-7OAI: oai:DiVA.org:liu-36015DiVA: diva2:256863
2006-05-02, Wranne-salen, Hälsouniversitet, Linköping, 08:30 (Swedish)
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