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Mendelian resistance to human norovirus infections
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Molecular Virology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Molecular Virology.
2006 (English)In: Seminars in Immunology, ISSN 1044-5323, Vol. 18, no 6, 375-386 p.Article in journal (Refereed) Published
Abstract [en]

Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages. Despite high infectivity of the virus and lack of long-term immunity, volunteer and authentic studies has suggested the existence of inherited protective factors. Recent studies have shown that histo-blood group antigens (HBGAs) and in particular secretor status controlled by the α1,2fucosyltransferase FUT2 gene determine susceptibility to norovirus infections, with nonsecretors (FUT2-/-), representing 20% of Europeans, being highly resistant to symptomatic infections with major strains of norovirus. Moreover, the capsid protein from distinct strains shows different HBGA specificities, suggesting a host-pathogen co-evolution driven by carbohydrate-protein interactions. © 2006.

Place, publisher, year, edition, pages
2006. Vol. 18, no 6, 375-386 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-36034DOI: 10.1016/j.smim.2006.07.009Local ID: 29530OAI: oai:DiVA.org:liu-36034DiVA: diva2:256882
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Kindberg, ElinSvensson, Lennart

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