Mendelian resistance to human norovirus infections
2006 (English)In: Seminars in Immunology, ISSN 1044-5323, Vol. 18, no 6, 375-386 p.Article in journal (Refereed) Published
Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages. Despite high infectivity of the virus and lack of long-term immunity, volunteer and authentic studies has suggested the existence of inherited protective factors. Recent studies have shown that histo-blood group antigens (HBGAs) and in particular secretor status controlled by the α1,2fucosyltransferase FUT2 gene determine susceptibility to norovirus infections, with nonsecretors (FUT2-/-), representing 20% of Europeans, being highly resistant to symptomatic infections with major strains of norovirus. Moreover, the capsid protein from distinct strains shows different HBGA specificities, suggesting a host-pathogen co-evolution driven by carbohydrate-protein interactions. © 2006.
Place, publisher, year, edition, pages
2006. Vol. 18, no 6, 375-386 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-36034DOI: 10.1016/j.smim.2006.07.009Local ID: 29530OAI: oai:DiVA.org:liu-36034DiVA: diva2:256882