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Immune regulatory T cells in siblings of children suffering from type 1 diabetes mellitus
Cell Immunotherapy Center, Masaryk University Brno, Czech Republic.
Dept of Pediatrics, Masaryk University Brno, Czech Republic.
Dept of Pediatrics, Masaryk University Brno, Czech Republic.
Dept of Pediatrics, Masaryk University Brno, Czech Republic.
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2006 (English)In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 64, no 5, 531-535 p.Article in journal (Refereed) Published
Abstract [en]

Patients with type 1 diabetes are suffering from defects in immune regulatory cells. Their siblings may be at increased risk of type 1 diabetes especially if they are carriers of certain human leucocyte antigen (HLA) alleles. In a prospective non-randomized study, we intended to evaluate 31 healthy siblings of paediatric patients with type 1 diabetes and explore immune regulatory populations of CD4+CD25+ T cells and natural killer (NK) T cells. Tested siblings of type 1 diabetes patients were stratified according to the HLA-associated risk of possible diabetes development. Immune regulatory function of CD4+CD25+ T cells was tested in vitro. Significant differences in CD4+CD25+ but not in NK T cells have been identified. Siblings of type 1 diabetes patients carrying high risk HLA alleles (DQA1*05, DQB1*0201, DQB1*0302) had significantly lower number of immune regulatory CD4+CD25+ T cells than the age-matched healthy controls or siblings carrying low-risk HLA alleles (DQB1*0301, DQB1*0603, DQB1*0602). Regulatory function of CD4+CD25+ T cells demonstrated a dose-escalation effect. In siblings of type 1 diabetes patients, the defect in immune regulatory CD4+CD25+ T cells exists in association with genetic HLA-linked risk for type 1 diabetes. © 2006 The Authors.

Place, publisher, year, edition, pages
2006. Vol. 64, no 5, 531-535 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-36060DOI: 10.1111/j.1365-3083.2006.01837.xLocal ID: 29632OAI: oai:DiVA.org:liu-36060DiVA: diva2:256908
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13

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Faresjö, Maria

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