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Chronic psychological stress in rats induces intestinal sensitization to luminal antigens
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of surgery. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
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2006 (English)In: American Journal of Pathology, ISSN 0002-9440, Vol. 168, no 1, 104-114 p.Article in journal (Refereed) Published
Abstract [en]

There is increasing evidence that stress plays a role in the pathophysiology of chronic intestinal disorders, but the mechanisms remain unclear. Previous studies in rats have revealed that stress decreases gut barrier function and allows excessive uptake of luminal material. Here, we investigated whether chronic psychological stress acts to induce sensitization of intestinal tissues to oral antigens. Rats were subjected to 1 hour per day of water avoidance stress or sham stress daily for 10 days, and horseradish peroxidase (HRP) was delivered by gavage on day 5. Studies to determine sensitization were conducted on day 20. All stressed rats developed HRP-specific IgE antibodies, antigen-induced intestinal secretion, and increased numbers of inflammatory cells in gut mucosa. luminal URP was absorbed more readily by enterocytes of stressed animals. In addition, stressed rats had increased expression of interleukin-4 and decreased expression of Interferon-γ in gut mucosa, a cytokine profile that is typical of allergic conditions. Treatment of stressed rats with an antagonist to corticotropin-releasing hormone (previously shown to inhibit stress-enhanced gut permeability) eliminated the manifestations of intestinal hypersensitivity. Our results indicate that the presence of oral antigen during chronic psychological stress alters the immune response (to sensitization rather than oral tolerance) and causes subsequent antigen-induced gut pathophysiology. Copyright © American Society for Investigative Pathology.

Place, publisher, year, edition, pages
2006. Vol. 168, no 1, 104-114 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-36104DOI: 10.2353/ajpath.2006.050575Local ID: 29905OAI: diva2:256952
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Söderholm, Johan D
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Faculty of Health SciencesDivision of surgeryDepartment of Surgery in Östergötland
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