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Proenkephalin-A mRNA is widely expressed in tissues of the human gastrointestinal tract
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of cell biology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Molecular Biological Techniques.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of cell biology.
2006 (English)In: European Surgical Research, ISSN 0014-312X, E-ISSN 1421-9921, Vol. 38, no 5, 464-468 p.Article in journal (Refereed) Published
Abstract [en]

Background: It has been shown that the non-opioid effects of Met-enkephalin, which is derived from proenkephalin-A, are mediated through a specific opioid growth factor (OGF) receptor which is assumed to be involved in the control of cell growth. The expression and tissue location of proenkephalin-A mRNA in the gastrointestinal tract remains largely unknown. Methods: In this study we have analyzed the expression of proenkephalin-A mRNA in the human esophagus, gastrointestinal tract and surrounding organs by means of reverse-transcriptase PCR (RT-PCR). Results: The present study demonstrates proenkephalin-A mRNA expression in the human esophagus, gastrointestinal tract, pancreas, and gallbladder. Conclusion: The present study demonstrates proenkephalin-A mRNA expression in regions of the human esophagus, gastrointestinal tract, pancreas, and gallbladder tissues which provides information for the future mapping of proenkephalin-A mRNA and protein expression/co-expression at the cellular level. Copyright © 2006 S. Karger AG.

Place, publisher, year, edition, pages
2006. Vol. 38, no 5, 464-468 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-36106DOI: 10.1159/000095414Local ID: 29908OAI: oai:DiVA.org:liu-36106DiVA: diva2:256954
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13

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Monstein, Hans-JurgGrahn, Niclas

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