Proenkephalin-A mRNA is widely expressed in tissues of the human gastrointestinal tract
2006 (English)In: European Surgical Research, ISSN 0014-312X, Vol. 38, no 5, 464-468 p.Article in journal (Refereed) Published
Background: It has been shown that the non-opioid effects of Met-enkephalin, which is derived from proenkephalin-A, are mediated through a specific opioid growth factor (OGF) receptor which is assumed to be involved in the control of cell growth. The expression and tissue location of proenkephalin-A mRNA in the gastrointestinal tract remains largely unknown. Methods: In this study we have analyzed the expression of proenkephalin-A mRNA in the human esophagus, gastrointestinal tract and surrounding organs by means of reverse-transcriptase PCR (RT-PCR). Results: The present study demonstrates proenkephalin-A mRNA expression in the human esophagus, gastrointestinal tract, pancreas, and gallbladder. Conclusion: The present study demonstrates proenkephalin-A mRNA expression in regions of the human esophagus, gastrointestinal tract, pancreas, and gallbladder tissues which provides information for the future mapping of proenkephalin-A mRNA and protein expression/co-expression at the cellular level. Copyright © 2006 S. Karger AG.
Place, publisher, year, edition, pages
2006. Vol. 38, no 5, 464-468 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-36106DOI: 10.1159/000095414Local ID: 29908OAI: oai:DiVA.org:liu-36106DiVA: diva2:256954