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Cerebrospinal fluid kynurenic acid in male and female controls - Correlation with monoamine metabolites and influences of confounding factors
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Psychiatry. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
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2007 (English)In: Journal of Psychiatric Research, ISSN 0022-3956, Vol. 41, no 1-2, 144-151 p.Article in journal (Refereed) Published
Abstract [en]

The concentrations of the tryptophan metabolite kynurenic acid (KYNA) and the monoamine metabolites homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxyphenylglycol (HMPG) were determined in the cerebrospinal fluid (CSF) from 43 healthy volunteers (30 males and 13 females). Healthy female controls displayed higher CSF concentration of KYNA (1.91 nM ± 0.20) compared to healthy male controls (1.06 nM ± 0.07) and lower CSF levels of HMPG (39.2 nM ± 2.0 and 43.4 ± 1.2, respectively). CSF levels of HVA and 5-HIAA did not differ between females (181.3 nM ± 21.9 and 93.7 nM ± 11.4, respectively) and males (138.9 nM ± 12.6 and 74.8 nM ± 5.9, respectively). Positive intercorrelations were found between CSF KYNA, HVA and 5-HIAA while CSF content of HMPG did not correlate with KYNA or the other monoamine metabolites in CSF. A negative correlation was found between back length and CSF concentrations of KYNA, HVA and 5-HIAA and also between CSF KYNA levels and body height. The results of the present study suggest that concentrations of KYNA and the monoamine metabolites in CSF from healthy controls are dependent on gender and back length, which must be taken in consideration when analysing mixed groups of men and women. The higher KYNA concentration found in female controls compared to male might be attributed to a shorter back in women compared to men. Furthermore, these findings suggest that increased KYNA formation is associated with an increased dopamine and serotonin turnover. © 2005 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2007. Vol. 41, no 1-2, 144-151 p.
Keyword [en]
Homovanillic acid; 5-Hydroxy-indoleacetic acid; 4-Hydroxy-3methoxyphenylglycol; Human; Cerebrospinal fluid
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-36138DOI: 10.1016/j.jpsychires.2005.12.001Local ID: 30085OAI: diva2:256986
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2011-01-11

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Nordin, Conny
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